DegronMD

Uniprot ID: Q6UB98

Source protein: Ankyrin repeat domain-containing protein 12

Source gene: ANKRD12

Class: DEG_APCC_KENBOX_2

Location: 494:498

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.836

ASA_SCORE: 104.5

COIL: 0.8296

CONS_SCORE: 0.4126

DSS_SCORE: 0.5556

HELIX: 0.1164

FCONS_SCORE: 1.1767

RIG_SCORE: 0.6725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R499K	TCGA-85-7696	LUSC	TCGA	GKENT	DEG_APCC_KENBOX_2	0.3056
p.R499K	DO26671	LUSC	ICGC	GKENT	DEG_APCC_KENBOX_2	0.3056
p.K492N	TCGA-DK-A2I1	BLCA	TCGA	GKENT	DEG_APCC_KENBOX_2	0.2778
p.K492N	DO444	BLCA	ICGC	GKENT	DEG_APCC_KENBOX_2	0.2778
p.V505L	TCGA-L9-A7SV	LUAD	TCGA	GKENT	DEG_APCC_KENBOX_2	0.1389
p.V505L	DO49875	LUAD	ICGC	GKENT	DEG_APCC_KENBOX_2	0.1389
p.Q486E	SIDM01449	Pancreatic Carcinoma	GDSC	GKENT	DEG_APCC_KENBOX_2	0.1111
p.Q486E	ACH-000517	Pancreatic Cancer	CCLE	GKENT	DEG_APCC_KENBOX_2	0.1111
p.D506G	NCI-H1993	lung	COSMIC	GKENT	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_APCC_KENBOX_2	494:498	GKENT	APC,CDC20,FZR1	0.836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons