DegronMD - Q96JM7(L3MBTL3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P91A	TCGA-13-0757	OV	TCGA	PPAY	ITCH	84:87	Mutation rewiring degron network	0.2222
p.P91A	DO32576	OV	ICGC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.2222
p.D14E	TCGA-18-3414	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.1944
p.D14E	DO26629	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.1944
p.P597T	TCGA-55-7573	LUAD	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation altering degron motif	0.5919
p.P597T	DO23675	LUAD	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation altering degron motif	0.5919
p.S90C	TCGA-85-8071	LUSC	TCGA	PPAY	ITCH	84:87	Mutation rewiring degron network	0.25
p.S90C	DO26755	LUSC	ICGC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.25
p.I595M	TCGA-A5-A0G2	UCEC	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation altering degron motif	0.6507
p.I595M	DO41235	UCEC	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation altering degron motif	0.6507
p.R594H	TCGA-B5-A0JY	UCEC	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation altering degron motif	0.7133
p.R594H	TCGA-CM-5861	COAD	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation altering degron motif	0.7133
p.R594H	TCGA-IQ-7630	HNSC	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation altering degron motif	0.7133
p.R594H	DO7918	COAD	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation altering degron motif	0.7133
p.R594H	DO14654	HNSC	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation altering degron motif	0.7133
p.R594H	DO43041	UCEC	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation altering degron motif	0.7133
p.R599C	TCGA-BR-8296	STAD	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.3056
p.R599C	DO38539	STAD	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.3056
p.R599C	SIDM00217	Colorectal Carcinoma	GDSC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.3056
p.R599C	ACH-000999	Colon/Colorectal Cancer	CCLE	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.3056
p.R599C	SNU-1040	large intestine	COSMIC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.3056
p.P76A	TCGA-C8-A12P	BRCA	TCGA	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1389
p.P76A	TCGA-C8-A12P	BRCA	TCGA	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1111
p.P76A	DO4000	BRCA	ICGC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1389
p.P76A	DO4000	BRCA	ICGC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1111
p.G10C	TCGA-D3-A1QA	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.3056
p.G10C	DO47469	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.3056
p.M52I	TCGA-EE-A17X	SKCM	TCGA	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1389
p.M52I	TCGA-ET-A39R	THCA	TCGA	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1389
p.M52I	DO37931	SKCM	ICGC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1389
p.M52I	DO39552	THCA	ICGC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1389
p.V97F	TCGA-EE-A29X	SKCM	TCGA	PPAY	ITCH	84:87	Mutation rewiring degron network	0.0556
p.V97F	TCGA-FS-A1ZN	SKCM	TCGA	PPAY	ITCH	84:87	Mutation rewiring degron network	0.0556
p.V97F	DO37595	SKCM	ICGC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.0556
p.V97F	DO38165	SKCM	ICGC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.0556
p.V66E	TCGA-EE-A2MI	SKCM	TCGA	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation altering degron motif	0.7693
p.V66E	DO37531	SKCM	ICGC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation altering degron motif	0.7693
p.P606L	TCGA-EO-A22U	UCEC	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.1111
p.P606L	DO43755	UCEC	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.1111
p.P77Q	TCGA-G2-A2EJ	BLCA	TCGA	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1111
p.P77Q	TCGA-G2-A2EJ	BLCA	TCGA	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1389
p.P77Q	DO554	BLCA	ICGC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1111
p.P77Q	DO554	BLCA	ICGC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1389
p.A60T	TCGA-HU-8602	STAD	TCGA	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation altering degron motif	0.6028
p.A60T	DO47829	STAD	ICGC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation altering degron motif	0.6028
p.S4Y	TCGA-JW-A5VL	CESC	TCGA	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.3056
p.S4Y	DO49976	CESC	ICGC	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.3056
p.E12K	TCGA-TN-A7HJ	HNSC	TCGA	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.25
p.E12K	DO219077	HNSC	ICGC	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.25
p.S6F	DO225354	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.7982
p.W88L	DO228986	LICA	ICGC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.3056
p.W88C	DO45049	LINC	ICGC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.3056
p.P92S	DO231075	LUSC	ICGC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92S	SIDM00367	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92S	SIDM00370	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92S	SIDM00463	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92S	SIDM00296	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92S	SIDM00581	Glioblastoma	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92S	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92S	SIDM00383	Gastric Carcinoma	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92S	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92S	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92S	SIDM00324	Neuroblastoma	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92S	SIDM00603	Head and Neck Carcinoma	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P95L	DO220877	MELA	ICGC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1111
p.P95S	DO229211	THCA	ICGC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1111
p.A58S	SIDM01245	T-Lymphoblastic Leukemia	GDSC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.3056
p.A58S	BE-13	haematopoietic and lymphoid tissue	COSMIC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.3056
p.E53G	SIDM00082	Melanoma	GDSC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1667
p.E53G	ACH-001190	Skin Cancer	CCLE	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1667
p.E53G	SK-MEL-2	skin	COSMIC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1667
p.P81S	SIDM00789	Colorectal Carcinoma	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.25
p.P81S	ACH-000997	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	84:87	Mutation rewiring degron network	0.25
p.P81S	ACH-001061	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	84:87	Mutation rewiring degron network	0.25
p.P81S	HCT-15	large intestine	COSMIC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.25
p.P92R	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92R	ACH-000809	Esophageal Cancer	CCLE	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.P92R	KYSE-410	oesophagus	COSMIC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1944
p.L600V	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.2778
p.L600V	ACH-000488	Esophageal Cancer	CCLE	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.2778
p.L600V	TE-11	oesophagus	COSMIC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.2778
p.N54S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1944
p.N54S	ACH-001233	Lung Cancer	CCLE	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1944
p.N54S	VMRC-LCD	lung	COSMIC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1944
p.S601I	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation blocking phosphorylation signal	0.6944
p.S601I	ACH-000951	Lung Cancer	CCLE	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation blocking phosphorylation signal	0.6944
p.S601I	NCI-H2342	lung	COSMIC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation blocking phosphorylation signal	0.6944
p.F13L	SIDM00850	Gastric Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.F13L	ACH-000880	Gastric Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.F13L	AGS	stomach	COSMIC	ASSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.E49D	SIDM01611	Endometrial Carcinoma	GDSC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.0556
p.E49D	ACH-000996	Endometrial/Uterine Cancer	CCLE	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.0556
p.P605L	SIDM01768	Melanoma	GDSC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.1389
p.P605L	ACH-000899	Skin Cancer	CCLE	KDRIFPD	LIG_APCC_ABBAyCdc20_2	592:598	Mutation rewiring degron network	0.1389
p.P77L	ACH-000230	Non-Cancerous	CCLE	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1111
p.P77L	ACH-000230	Non-Cancerous	CCLE	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1389
p.P81L	ACH-001745	Sarcoma	CCLE	PPAY	ITCH	84:87	Mutation rewiring degron network	0.25
p.K76R	YAPC	pancreas	COSMIC	TATTTWMVPTA	DEG_COP1_1	59:69	Mutation rewiring degron network	0.1389
p.K76R	YAPC	pancreas	COSMIC	PPAY	ITCH	84:87	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

L3MBTL3

UniProt ID: Q96JM7

Entrez ID: 84456

Protein name: Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for L3MBTL3 in