DegronMD

Uniprot ID: Q96JM7

Source protein: Lethal

Source gene: L3MBTL3

Class: LIG_APCC_ABBAyCdc20_2

Location: 592:598

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5735

ASA_SCORE: 79.4714

COIL: 0.6366

CONS_SCORE: 0.4627

DSS_SCORE: 0.4967

HELIX: 0.1766

FCONS_SCORE: 0.9349

RIG_SCORE: 0.7659

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P597T	TCGA-55-7573	LUAD	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.5919
p.P597T	DO23675	LUAD	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.5919
p.I595M	TCGA-A5-A0G2	UCEC	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.6507
p.I595M	DO41235	UCEC	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.6507
p.R594H	TCGA-B5-A0JY	UCEC	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.7133
p.R594H	TCGA-CM-5861	COAD	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.7133
p.R594H	TCGA-IQ-7630	HNSC	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.7133
p.R594H	DO7918	COAD	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.7133
p.R594H	DO14654	HNSC	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.7133
p.R594H	DO43041	UCEC	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.7133
p.R599C	TCGA-BR-8296	STAD	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R599C	DO38539	STAD	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R599C	SIDM00217	Colorectal Carcinoma	GDSC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R599C	ACH-000999	Colon/Colorectal Cancer	CCLE	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R599C	SNU-1040	large_intestine	COSMIC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P606L	TCGA-EO-A22U	UCEC	TCGA	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P606L	DO43755	UCEC	ICGC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.L600V	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.L600V	ACH-000488	Esophageal Cancer	CCLE	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.L600V	TE-11	oesophagus	COSMIC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S601I	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.6944
p.S601I	ACH-000951	Lung Cancer	CCLE	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.6944
p.S601I	NCI-H2342	lung	COSMIC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.6944
p.P605L	SIDM01768	Melanoma	GDSC	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P605L	ACH-000899	Skin Cancer	CCLE	KDRIFPD	LIG_APCC_ABBAyCdc20_2	0.1389

Drug responses associated with L3MBTL3 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R210W (No)	GDSC	UNC1215	6.7012
SIDM00315	GBM\|glioma	p.S256P (No)	GDSC	UNC1215	11.8707
SIDM00966	OV\|ovary	p.V286I (No)	GDSC	UNC1215	8.4214
SIDM00348	ESCA\|oesophagus	p.L600V (Yes)	GDSC	UNC1215	10.0945
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.A287T (No)	GDSC	UNC1215	6.1158
SIDM00550	ESCA\|oesophagus	p.S134F (No)	GDSC	UNC1215	10.1563
SIDM01174	CESC\|cervix	p.G737E (No)	GDSC	UNC1215	17.8715
SIDM00341	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y301C (No)	GDSC	UNC1215	14.1371
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R145W (No)	GDSC	UNC1215	3.5252
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.N54S (No)	GDSC	UNC1215	7.131
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.S579C (No)	GDSC	UNC1215	32.5494
SIDM00411	PAAD\|pancreas	p.K101R (No)	GDSC	UNC1215	21.8633
SIDM00117	LUAD\|lung_NSCLC_adenocarcinoma	p.E712G (No)	GDSC	UNC1215	23.4909
SIDM00117	LUAD\|lung_NSCLC_adenocarcinoma	p.E712D (No)	GDSC	UNC1215	23.4909
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R145W (No)	GDSC	UNC1215	14.685
SIDM00425	OV\|ovary	p.R145W (No)	GDSC	UNC1215	17.3986
SIDM00217	COREAD\|large_intestine	p.R210L (No)	GDSC	UNC1215	11.3851
SIDM00217	COREAD\|large_intestine	p.R372Q (No)	GDSC	UNC1215	11.3851
SIDM00217	COREAD\|large_intestine	p.R599C (Yes)	GDSC	UNC1215	11.3851
SIDM00082	SKCM\|melanoma	p.E53G (No)	GDSC	UNC1215	39.4978
SIDM00889	CESC\|cervix	p.G136R (No)	GDSC	UNC1215	9.7675
SIDM00660	COREAD\|large_intestine	p.R210W (No)	GDSC	UNC1215	15.1239
SIDM01245	ALL\|lymphoblastic_leukemia	p.A58S (No)	GDSC	UNC1215	5.1078
SIDM01189	GBM\|glioma	p.I388F (No)	GDSC	UNC1215	28.0837
SIDM01242	SKCM\|melanoma	p.R145W (No)	GDSC	UNC1215	19.5414
SIDM00789	COREAD\|large_intestine	p.P81S (No)	GDSC	UNC1215	14.2422
SIDM00789	COREAD\|large_intestine	p.W415R (No)	GDSC	UNC1215	14.2422
SIDM00534	COREAD\|large_intestine	p.S524Y (No)	GDSC	UNC1215	12.3123
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.L346H (No)	GDSC	UNC1215	7.228
SIDM01033	BLCA\|bladder	p.R145W (No)	GDSC	UNC1215	9.5862
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S601I (Yes)	GDSC	UNC1215	14.8032
SIDM01110	LIHC\|liver	p.T746A (No)	GDSC	UNC1215	9.0866
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.F298L (No)	GDSC	UNC1215	14.7152
SIDM00549	ALL\|lymphoblastic_leukemia	p.P461S (No)	GDSC	UNC1215	13.2877
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.I364T (No)	GDSC	UNC1215	16.4385
SIDM01259	ALL\|lymphoblastic_leukemia	p.P525L (No)	GDSC	UNC1215	17.2582
SIDM01040	OV\|ovary	p.R145W (No)	GDSC	UNC1215	16.2436
SIDM00659	GBM\|glioma	p.R171Q (No)	GDSC	UNC1215	13.1123
SIDM01104	SKCM\|melanoma	p.T644P (No)	GDSC	UNC1215	17.0795
SIDM00481	OV\|ovary	p.E338K (No)	GDSC	UNC1215	19.1246
SIDM00562	BRCA\|breast	p.C304F (No)	GDSC	UNC1215	14.7113
SIDM00332	BRCA\|breast	p.Q352E (No)	GDSC	UNC1215	28.1858

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KDRIFPD

Degron related mutations and impact score

Drug responses associated with L3MBTL3 mutations

All proteins holding degron of KDRIFPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JM7	Lethal	LIG_APCC_ABBAyCdc20_2	592:598	KDRIFPD	APC,CDC20,FZR1	0.5735	More...