DegronMD

Uniprot ID: Q96JM7

Source protein: Lethal

Source gene: L3MBTL3

Class: DEG_COP1_1

Location: 59:69

E3 ligase: COP1

DEGRON score: 0.935

ASA_SCORE: 84.7182

COIL: 0.7774

CONS_SCORE: 0.405

DSS_SCORE: 0.5406

HELIX: 0.1149

FCONS_SCORE: 0.9936

RIG_SCORE: 0.7887

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P76A	TCGA-C8-A12P	BRCA	TCGA	TATTTWMVPTA	DEG_COP1_1	0.1389
p.P76A	DO4000	BRCA	ICGC	TATTTWMVPTA	DEG_COP1_1	0.1389
p.M52I	TCGA-EE-A17X	SKCM	TCGA	TATTTWMVPTA	DEG_COP1_1	0.1389
p.M52I	TCGA-ET-A39R	THCA	TCGA	TATTTWMVPTA	DEG_COP1_1	0.1389
p.M52I	DO37931	SKCM	ICGC	TATTTWMVPTA	DEG_COP1_1	0.1389
p.M52I	DO39552	THCA	ICGC	TATTTWMVPTA	DEG_COP1_1	0.1389
p.V66E	TCGA-EE-A2MI	SKCM	TCGA	TATTTWMVPTA	DEG_COP1_1	0.7693
p.V66E	DO37531	SKCM	ICGC	TATTTWMVPTA	DEG_COP1_1	0.7693
p.P77Q	TCGA-G2-A2EJ	BLCA	TCGA	TATTTWMVPTA	DEG_COP1_1	0.1111
p.P77Q	DO554	BLCA	ICGC	TATTTWMVPTA	DEG_COP1_1	0.1111
p.A60T	TCGA-HU-8602	STAD	TCGA	TATTTWMVPTA	DEG_COP1_1	0.6028
p.A60T	DO47829	STAD	ICGC	TATTTWMVPTA	DEG_COP1_1	0.6028
p.A58S	SIDM01245	T-Lymphoblastic Leukemia	GDSC	TATTTWMVPTA	DEG_COP1_1	0.3056
p.A58S	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	TATTTWMVPTA	DEG_COP1_1	0.3056
p.E53G	SIDM00082	Melanoma	GDSC	TATTTWMVPTA	DEG_COP1_1	0.1667
p.E53G	ACH-001190	Skin Cancer	CCLE	TATTTWMVPTA	DEG_COP1_1	0.1667
p.E53G	SK-MEL-2	skin	COSMIC	TATTTWMVPTA	DEG_COP1_1	0.1667
p.N54S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	TATTTWMVPTA	DEG_COP1_1	0.1944
p.N54S	ACH-001233	Lung Cancer	CCLE	TATTTWMVPTA	DEG_COP1_1	0.1944
p.N54S	VMRC-LCD	lung	COSMIC	TATTTWMVPTA	DEG_COP1_1	0.1944
p.E49D	SIDM01611	Endometrial Carcinoma	GDSC	TATTTWMVPTA	DEG_COP1_1	0.0556
p.E49D	ACH-000996	Endometrial/Uterine Cancer	CCLE	TATTTWMVPTA	DEG_COP1_1	0.0556
p.P77L	ACH-000230	Non-Cancerous	CCLE	TATTTWMVPTA	DEG_COP1_1	0.1111
p.K76R	YAPC	pancreas	COSMIC	TATTTWMVPTA	DEG_COP1_1	0.1389

Drug responses associated with L3MBTL3 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R210W (No)	GDSC	UNC1215	6.7012
SIDM00315	GBM\|glioma	p.S256P (No)	GDSC	UNC1215	11.8707
SIDM00966	OV\|ovary	p.V286I (No)	GDSC	UNC1215	8.4214
SIDM00348	ESCA\|oesophagus	p.L600V (No)	GDSC	UNC1215	10.0945
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.A287T (No)	GDSC	UNC1215	6.1158
SIDM00550	ESCA\|oesophagus	p.S134F (No)	GDSC	UNC1215	10.1563
SIDM01174	CESC\|cervix	p.G737E (No)	GDSC	UNC1215	17.8715
SIDM00341	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y301C (No)	GDSC	UNC1215	14.1371
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R145W (No)	GDSC	UNC1215	3.5252
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.N54S (Yes)	GDSC	UNC1215	7.131
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.S579C (No)	GDSC	UNC1215	32.5494
SIDM00411	PAAD\|pancreas	p.K101R (No)	GDSC	UNC1215	21.8633
SIDM00117	LUAD\|lung_NSCLC_adenocarcinoma	p.E712G (No)	GDSC	UNC1215	23.4909
SIDM00117	LUAD\|lung_NSCLC_adenocarcinoma	p.E712D (No)	GDSC	UNC1215	23.4909
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R145W (No)	GDSC	UNC1215	14.685
SIDM00425	OV\|ovary	p.R145W (No)	GDSC	UNC1215	17.3986
SIDM00217	COREAD\|large_intestine	p.R210L (No)	GDSC	UNC1215	11.3851
SIDM00217	COREAD\|large_intestine	p.R372Q (No)	GDSC	UNC1215	11.3851
SIDM00217	COREAD\|large_intestine	p.R599C (No)	GDSC	UNC1215	11.3851
SIDM00082	SKCM\|melanoma	p.E53G (Yes)	GDSC	UNC1215	39.4978
SIDM00889	CESC\|cervix	p.G136R (No)	GDSC	UNC1215	9.7675
SIDM00660	COREAD\|large_intestine	p.R210W (No)	GDSC	UNC1215	15.1239
SIDM01245	ALL\|lymphoblastic_leukemia	p.A58S (Yes)	GDSC	UNC1215	5.1078
SIDM01189	GBM\|glioma	p.I388F (No)	GDSC	UNC1215	28.0837
SIDM01242	SKCM\|melanoma	p.R145W (No)	GDSC	UNC1215	19.5414
SIDM00789	COREAD\|large_intestine	p.P81S (No)	GDSC	UNC1215	14.2422
SIDM00789	COREAD\|large_intestine	p.W415R (No)	GDSC	UNC1215	14.2422
SIDM00534	COREAD\|large_intestine	p.S524Y (No)	GDSC	UNC1215	12.3123
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.L346H (No)	GDSC	UNC1215	7.228
SIDM01033	BLCA\|bladder	p.R145W (No)	GDSC	UNC1215	9.5862
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S601I (No)	GDSC	UNC1215	14.8032
SIDM01110	LIHC\|liver	p.T746A (No)	GDSC	UNC1215	9.0866
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.F298L (No)	GDSC	UNC1215	14.7152
SIDM00549	ALL\|lymphoblastic_leukemia	p.P461S (No)	GDSC	UNC1215	13.2877
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.I364T (No)	GDSC	UNC1215	16.4385
SIDM01259	ALL\|lymphoblastic_leukemia	p.P525L (No)	GDSC	UNC1215	17.2582
SIDM01040	OV\|ovary	p.R145W (No)	GDSC	UNC1215	16.2436
SIDM00659	GBM\|glioma	p.R171Q (No)	GDSC	UNC1215	13.1123
SIDM01104	SKCM\|melanoma	p.T644P (No)	GDSC	UNC1215	17.0795
SIDM00481	OV\|ovary	p.E338K (No)	GDSC	UNC1215	19.1246
SIDM00562	BRCA\|breast	p.C304F (No)	GDSC	UNC1215	14.7113
SIDM00332	BRCA\|breast	p.Q352E (No)	GDSC	UNC1215	28.1858

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TATTTWMVPTA

Degron related mutations and impact score

Drug responses associated with L3MBTL3 mutations

All proteins holding degron of TATTTWMVPTA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JM7	Lethal	DEG_COP1_1	59:69	TATTTWMVPTA	COP1	0.935	More...