DegronMD

Uniprot ID: Q9NZP6

Source protein: Nuclear pore-associated protein 1

Source gene: NPAP1

Class: DEG_SPOP_SBC_1

Location: 676:680

E3 ligase: SPOP

DEGRON score: 0.9536

ASA_SCORE: 90.56

COIL: 0.9392

CONS_SCORE: 0.6045

DSS_SCORE: 0.4664

HELIX: 0.0238

FCONS_SCORE: 1.1044

RIG_SCORE: 0.6896

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S689L	TCGA-18-3409	LUSC	TCGA	PDTST	DEG_SPOP_SBC_1	0.0833
p.S689L	DO26444	LUSC	ICGC	PDTST	DEG_SPOP_SBC_1	0.0833
p.P674A	TCGA-50-5946	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.2778
p.P674A	DO24556	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.V682L	TCGA-64-5815	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.2778
p.V682L	DO23578	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.S684C	TCGA-91-6830	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.2222
p.S684C	DO25867	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.2222
p.T680I	TCGA-AX-A2HC	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	0.7078
p.T680I	DO41572	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.7078
p.P674S	TCGA-EE-A182	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	0.2778
p.P674S	DO37814	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.T680N	DO23496	LINC	ICGC	PDTST	DEG_SPOP_SBC_1	0.7055
p.T680N	DO45053	LINC	ICGC	PDTST	DEG_SPOP_SBC_1	0.7055
p.L668M	DO231152	LUSC	ICGC	PDTST	DEG_SPOP_SBC_1	0.1111
p.N683S	DO228406	MALY	ICGC	PDTST	DEG_SPOP_SBC_1	0.25
p.P675S	DO220894	MELA	ICGC	PDTST	DEG_SPOP_SBC_1	0.3056
p.P675S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.3056
p.P676S	DO222753	MELA	ICGC	PDTST	DEG_SPOP_SBC_1	0.6752
p.F667L	DO221541	PACA	ICGC	PDTST	DEG_SPOP_SBC_1	0.0833
p.P674T	SIDM00088	Prostate Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2778
p.P674T	PC-3	prostate	COSMIC	PDTST	DEG_SPOP_SBC_1	0.2778
p.A688S	SIDM00660	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.1111
p.A688S	ACH-000985	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.1111
p.A688S	LS-411N	large_intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	0.1111
p.N683D	SIDM00837	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.25
p.N683D	ACH-000958	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.25
p.N683D	SW48	large_intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	0.25
p.P675H	SIDM00217	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.3056
p.P675H	ACH-000999	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.3056
p.P675H	SNU-1040	large_intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	0.3056
p.T687A	FADU	upper_aerodigestive_tract	COSMIC	PDTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDTST

Degron related mutations and impact score

Drug responses associated with NPAP1 mutations

All proteins holding degron of PDTST