DegronMD

Uniprot ID: Q8WZ75

Source protein: Roundabout homolog 4

Source gene: ROBO4

Class: DEG_SPOP_SBC_1

Location: 576:580

E3 ligase: SPOP

DEGRON score: 0.9187

ASA_SCORE: 49.4

COIL: 0.7118

CONS_SCORE: 0.6747

DSS_SCORE: 0.3762

HELIX: 0.0524

FCONS_SCORE: 1.0558

RIG_SCORE: 0.7347

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D566N	TCGA-86-8281	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.0556
p.D566N	DO26318	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.0556
p.I586M	TCGA-DR-A0ZM	CESC	TCGA	PDTST	DEG_SPOP_SBC_1	0.1667
p.I586M	DO6254	CESC	ICGC	PDTST	DEG_SPOP_SBC_1	0.1667
p.G571C	TCGA-EO-A22R	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	0.1944
p.G571C	DO42713	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.1944
p.A587V	DO233737	GACA	ICGC	PDTST	DEG_SPOP_SBC_1	0.1389
p.R568Q	DO233888	GACA	ICGC	PDTST	DEG_SPOP_SBC_1	0.1111
p.P570L	DO11854	GBM	ICGC	PDTST	DEG_SPOP_SBC_1	0.1667
p.D577E	DO229019	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.5647
p.L574P	DO224638	LUSC	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.A587P	SIDM00660	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.1389
p.A587P	ACH-000985	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.1389
p.A587P	LS-411N	large_intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	0.1389
p.L589M	SIDM00057	Neuroblastoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.0833
p.L589M	SIDM00552	Rhabdomyosarcoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.0833
p.L589M	ACH-000607	Rhabdoid	CCLE	PDTST	DEG_SPOP_SBC_1	0.0833
p.L589M	KYM-1	soft_tissue	COSMIC	PDTST	DEG_SPOP_SBC_1	0.0833
p.V572M	SIDM00560	Gastric Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.V572M	MKN7	stomach	COSMIC	PDTST	DEG_SPOP_SBC_1	0.2222
p.E578K	MEL-HO	skin	COSMIC	PDTST	DEG_SPOP_SBC_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons