DegronMD

Uniprot ID: Q96LR2

Source protein: Leucine rich adaptor protein 1

Source gene: LURAP1

Class: DEG_SPOP_SBC_1

Location: 131:135

E3 ligase: SPOP

DEGRON score: 0.9852

ASA_SCORE: 81.76

COIL: 0.9226

CONS_SCORE: 0.625

DSS_SCORE: 0.5493

HELIX: 0.0538

FCONS_SCORE: 0.7417

RIG_SCORE: 0.6869

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G125C	TCGA-17-Z045	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.1667
p.P131T	TCGA-28-1757	GBM	TCGA	PDTST	DEG_SPOP_SBC_1	0.7031
p.P131T	DO12166	GBM	ICGC	PDTST	DEG_SPOP_SBC_1	0.7031
p.D137N	TCGA-2W-A8YY	CESC	TCGA	PDTST	DEG_SPOP_SBC_1	0.2778
p.D137N	DO223732	CESC	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.R121C	TCGA-AZ-6601	COAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.0556
p.R121C	DO8119	COAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.0556
p.R121S	TCGA-BF-A1PZ	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	0.0556
p.R121S	DO50279	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.0556
p.R124L	DO228976	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.1389
p.R124Q	ACH-001548	Neuroblastoma	CCLE	PDTST	DEG_SPOP_SBC_1	0.1389
p.S143F	ACH-002045	Head and Neck Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons