DegronMD

Uniprot ID: Q9NZP6

Source protein: Nuclear pore-associated protein 1

Source gene: NPAP1

Class: DEG_SPOP_SBC_1

Location: 801:805

E3 ligase: SPOP

DEGRON score: 0.9687

ASA_SCORE: 84.32

COIL: 0.9206

CONS_SCORE: 0.6205

DSS_SCORE: 0.3848

HELIX: 0.0552

FCONS_SCORE: 0.9764

RIG_SCORE: 0.7081

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S809I	TCGA-17-Z045	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.2222
p.S804Y	TCGA-49-AARE	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.712
p.S804Y	DO218922	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.712
p.A813S	TCGA-55-7725	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.1111
p.A813S	DO24636	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.1111
p.T803S	TCGA-56-8622	LUSC	TCGA	PDTST	DEG_SPOP_SBC_1	0.6005
p.T803S	DO45449	LUSC	ICGC	PDTST	DEG_SPOP_SBC_1	0.6005
p.A810D	TCGA-69-7979	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.1944
p.A810D	DO23874	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.1944
p.S794I	TCGA-AJ-A5DW	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	0.1389
p.S794I	DO50075	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.1389
p.P800S	TCGA-D3-A8GL	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	0.3056
p.P800S	DO50287	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.3056
p.P796S	TCGA-DA-A1HV	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	0.1944
p.P796S	DO37659	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.1944
p.D791N	TCGA-EE-A29M	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	0.0556
p.D791N	TCGA-FS-A1ZZ	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	0.0556
p.D791N	DO37412	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.0556
p.D791N	DO37404	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.0556
p.S804F	TCGA-ER-A193	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	0.7982
p.S804F	DO47368	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.7982
p.S794R	TCGA-HU-A4GH	STAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.1389
p.S794R	DO47743	STAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.1389
p.F792V	DO222762	COCA	ICGC	PDTST	DEG_SPOP_SBC_1	0.0833
p.V799A	DO228114	EOPC	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.S794G	DO234230	ESAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.1389
p.V807L	DO231976	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.M798T	DO23444	LINC	ICGC	PDTST	DEG_SPOP_SBC_1	0.25
p.F792C	DO218886	SKCA	ICGC	PDTST	DEG_SPOP_SBC_1	0.0833
p.P796H	SIDM00216	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.1944
p.P796H	ACH-000989	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.1944
p.P796H	SNU-175	large_intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	0.1944
p.S811F	SIDM00630	Breast Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.1667
p.S811F	ACH-000876	Breast Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.1667
p.I797V	SIDM01040	Ovarian Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00553	Acute Myeloid Leukemia	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00607	Glioblastoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00589	Oral Cavity Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00571	Pancreatic Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00040	Gastric Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00282	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00276	Biliary Tract Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00239	Kidney Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00560	Gastric Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM00591	Oral Cavity Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM01551	Gastric Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM01498	Acute Myeloid Leukemia	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.I797V	SIDM01776	Plasma Cell Myeloma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.M798I	SIDM00488	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.25
p.M798I	ACH-002345	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.25
p.M798I	CaR-1	large_intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDTST

Degron related mutations and impact score

Drug responses associated with NPAP1 mutations

All proteins holding degron of PDTST