DegronMD

Uniprot ID: Q9NZP6

Source protein: Nuclear pore-associated protein 1

Source gene: NPAP1

Class: DEG_SCF_FBW7_1

Location: 497:503

E3 ligase: FBXW7

DEGRON score: 0.8747

ASA_SCORE: 85.6143

COIL: 0.9753

CONS_SCORE: 0.6206

DSS_SCORE: 0.6617

HELIX: 0.0097

FCONS_SCORE: 0.9389

RIG_SCORE: 0.5244

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P509H	TCGA-17-Z028	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.P509H	TCGA-AX-A2HD	UCEC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.P509H	DO42608	UCEC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.R513T	TCGA-17-Z056	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.0556
p.V488I	TCGA-22-4594	LUSC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.0833
p.V488I	TCGA-AG-A015	READ	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.0833
p.V488I	TCGA-AG-A01Y	READ	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.0833
p.V488I	DO27476	LUSC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.0833
p.V488I	DO37396	READ	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.0833
p.F507I	TCGA-29-2434	OV	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.2222
p.F507I	DO31360	OV	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.2222
p.S495Y	TCGA-2F-A9KO	BLCA	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.2778
p.S495Y	DO51859	BLCA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.2778
p.R513K	TCGA-3N-A9WC	SKCM	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.0556
p.R513K	DO51234	SKCM	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.0556
p.G489E	TCGA-44-A479	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.1111
p.G489E	DO23633	LUAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.1111
p.V488L	TCGA-73-A9RS	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.0833
p.V488L	DO51193	LUAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.0833
p.A491V	TCGA-AA-A01Z	COAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.A491V	DO8392	COAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.P500R	TCGA-BB-A5HY	HNSC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.7512
p.P500R	DO218979	HNSC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.7512
p.L493H	TCGA-BR-4184	STAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.2222
p.L493H	DO38328	STAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.2222
p.P501R	TCGA-BR-A4QI	STAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.6401
p.P501R	DO38523	STAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.6401
p.D496Y	TCGA-CV-7245	HNSC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.3056
p.D496Y	DO14322	HNSC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.3056
p.T512A	TCGA-DU-6392	LGG	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.0833
p.T512A	DO22237	LGG	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.0833
p.D496E	TCGA-HR-A5NC	SKCM	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.3056
p.D496E	DO51265	SKCM	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.3056
p.A490S	TCGA-IB-7651	PAAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.1389
p.A490S	DO46657	PAAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.1389
p.V487F	TCGA-K4-A3WS	BLCA	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.0556
p.V487F	DO480	BLCA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.0556
p.A491S	TCGA-MP-A4SV	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.A491S	DO45339	LUAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.A491S	SIDM00049	Colorectal Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.A491S	ACH-002233	Colon/Colorectal Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.A491S	DIFI	large_intestine	COSMIC	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.A490T	TCGA-UF-A71B	HNSC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.1389
p.A490T	DO52107	HNSC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.1389
p.S503F	DO48244	ESCA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.7982
p.S503F	SIDM01735	Biliary Tract Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	0.7982
p.S503T	DO233761	GACA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.6005
p.V511F	DO228976	LICA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.1111
p.P505T	DO228983	LICA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.2778
p.D496G	DO49189	PACA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.3056
p.S506F	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	0.25
p.S506F	ACH-000865	Esophageal Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	0.25
p.S506F	KYSE-450	oesophagus	COSMIC	PPTPPSS	DEG_SCF_FBW7_1	0.25
p.A491T	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.A491T	ACH-000916	Lung Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.A491T	NCI-H1573	lung	COSMIC	PPTPPSS	DEG_SCF_FBW7_1	0.1667
p.V487D	ACH-001413	Bladder Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SCF_FBW7_1	4619:4625	PPTPPSS	FBXW7	0.9983	More...
Q96QT6	PHD finger protein 12	DEG_SCF_FBW7_1	878:884	PPTPPSS	FBXW7	0.8927	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SCF_FBW7_1	497:503	PPTPPSS	FBXW7	0.8747	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPPSS

Degron related mutations and impact score

Drug responses associated with NPAP1 mutations

All proteins holding degron of PPTPPSS