DegronMD - Q96QT6(PHF12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S931L	TCGA-52-7809	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.7667
p.S931L	DO26746	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.7667
p.R894S	TCGA-64-5781	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.0556
p.R894S	DO23740	LUAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.0556
p.P167L	TCGA-69-7979	LUAD	TCGA	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation altering degron motif	0.7582
p.P167L	DO23874	LUAD	ICGC	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation altering degron motif	0.7582
p.R155Q	TCGA-A5-A0G2	UCEC	TCGA	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation rewiring degron network	0.0833
p.R155Q	DO41235	UCEC	ICGC	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation rewiring degron network	0.0833
p.R921Q	TCGA-A6-6781	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1389
p.R921Q	DO8447	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1389
p.T704M	TCGA-AA-A01R	COAD	TCGA	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.2778
p.T704M	DO7934	COAD	ICGC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.2778
p.E875D	TCGA-B5-A0JY	UCEC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.25
p.E875D	DO43041	UCEC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.25
p.E875D	SIDM01726	Ewing's Sarcoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.25
p.I885S	TCGA-B5-A11E	UCEC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.3056
p.I885S	DO41644	UCEC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.3056
p.I885F	TCGA-BP-4985	KIRC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.3056
p.I885F	DO20693	KIRC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.3056
p.A154T	TCGA-BP-5201	KIRC	TCGA	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation rewiring degron network	0.0556
p.A154T	DO17206	KIRC	ICGC	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation rewiring degron network	0.0556
p.A171V	TCGA-BR-4201	STAD	TCGA	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation rewiring degron network	0.3056
p.A171V	DO38707	STAD	ICGC	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation rewiring degron network	0.3056
p.V713L	TCGA-DA-A1IB	SKCM	TCGA	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation altering degron motif	0.6765
p.V713L	DO38033	SKCM	ICGC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation altering degron motif	0.6765
p.S169F	TCGA-DF-A2KU	UCEC	TCGA	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation altering degron motif	0.6871
p.S169F	DO223286	UCEC	ICGC	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation altering degron motif	0.6871
p.R163S	TCGA-DS-A0VM	CESC	TCGA	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation rewiring degron network	0.3056
p.R163S	DO6258	CESC	ICGC	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation rewiring degron network	0.3056
p.S937N	TCGA-DU-6407	LGG	TCGA	ASSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1944
p.S937N	DO22295	LGG	ICGC	ASSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1944
p.S870A	TCGA-EO-A22X	UCEC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.1111
p.S870A	DO43907	UCEC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.1111
p.S720F	TCGA-EO-A22X	UCEC	TCGA	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.2222
p.S720F	DO43907	UCEC	ICGC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.2222
p.S706P	TCGA-EO-A3B0	UCEC	TCGA	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation altering degron motif	0.6752
p.S706P	DO219773	UCEC	ICGC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation altering degron motif	0.6752
p.S709N	DO230312	COCA	ICGC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation altering degron motif	0.7069
p.S891T	DO48232	ESCA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	878:884	Mutation rewiring degron network	0.1389
p.S931P	DO233145	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.6752
p.L726I	DO228948	LICA	ICGC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.0556
p.S701R	DO229027	LICA	ICGC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.1944
p.A154D	DO229032	LICA	ICGC	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation rewiring degron network	0.0556
p.E158D	DO50907	LICA	ICGC	PGTPTSS	DEG_SCF_FBW7_1	164:170	Mutation rewiring degron network	0.1667
p.A939V	DO232761	PBCA	ICGC	ASSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1389
p.P702L	SIDM00057	Neuroblastoma	GDSC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.2222
p.P702L	ACH-000676	Brain Cancer	CCLE	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.2222
p.P702L	ACH-002389	Neuroblastoma	CCLE	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.2222
p.P702L	ACN	autonomic ganglia	COSMIC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.2222
p.S706F	SIDM00140	Melanoma	GDSC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation altering degron motif	0.7982
p.S706F	ACH-000968	Skin Cancer	CCLE	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation altering degron motif	0.7982
p.S706F	COLO-792	skin	COSMIC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation altering degron motif	0.7982
p.N719K	SIDM01387	Small Cell Lung Carcinoma	GDSC	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.25
p.N719K	ACH-000921	Lung Cancer	CCLE	SIGSALTVPSF	DEG_COP1_1	706:716	Mutation rewiring degron network	0.25
p.I934L	ACH-000299	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.2778

Kaplan plot for PHF12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHF12

UniProt ID: Q96QT6

Entrez ID: 57649

Protein name: PHD finger protein 12 (PHD factor 1) (Pf1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHF12 in