DegronMD

Uniprot ID: Q96QT6

Source protein: PHD finger protein 12

Source gene: PHF12

Class: DEG_SCF_FBW7_1

Location: 164:170

E3 ligase: FBXW7

DEGRON score: 0.9548

ASA_SCORE: 71.6857

COIL: 0.8864

CONS_SCORE: 0.3018

DSS_SCORE: 0.781

HELIX: 0.0546

FCONS_SCORE: 0.8825

RIG_SCORE: 0.525

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P167L	TCGA-69-7979	LUAD	TCGA	PGTPTSS	DEG_SCF_FBW7_1	0.7582
p.P167L	DO23874	LUAD	ICGC	PGTPTSS	DEG_SCF_FBW7_1	0.7582
p.R155Q	TCGA-A5-A0G2	UCEC	TCGA	PGTPTSS	DEG_SCF_FBW7_1	0.0833
p.R155Q	DO41235	UCEC	ICGC	PGTPTSS	DEG_SCF_FBW7_1	0.0833
p.A154T	TCGA-BP-5201	KIRC	TCGA	PGTPTSS	DEG_SCF_FBW7_1	0.0556
p.A154T	DO17206	KIRC	ICGC	PGTPTSS	DEG_SCF_FBW7_1	0.0556
p.A171V	TCGA-BR-4201	STAD	TCGA	PGTPTSS	DEG_SCF_FBW7_1	0.3056
p.A171V	DO38707	STAD	ICGC	PGTPTSS	DEG_SCF_FBW7_1	0.3056
p.S169F	TCGA-DF-A2KU	UCEC	TCGA	PGTPTSS	DEG_SCF_FBW7_1	0.6871
p.S169F	DO223286	UCEC	ICGC	PGTPTSS	DEG_SCF_FBW7_1	0.6871
p.R163S	TCGA-DS-A0VM	CESC	TCGA	PGTPTSS	DEG_SCF_FBW7_1	0.3056
p.R163S	DO6258	CESC	ICGC	PGTPTSS	DEG_SCF_FBW7_1	0.3056
p.A154D	DO229032	LICA	ICGC	PGTPTSS	DEG_SCF_FBW7_1	0.0556
p.E158D	DO50907	LICA	ICGC	PGTPTSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QT6	PHD finger protein 12	DEG_SCF_FBW7_1	164:170	PGTPTSS	FBXW7	0.9548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons