DegronMD

Uniprot ID: Q96QT6

Source protein: PHD finger protein 12

Source gene: PHF12

Class: DEG_SCF_FBW7_1

Location: 878:884

E3 ligase: FBXW7

DEGRON score: 0.8927

ASA_SCORE: 79.8429

COIL: 0.84

CONS_SCORE: 0.3613

DSS_SCORE: 0.5339

HELIX: 0.1493

FCONS_SCORE: 0.7712

RIG_SCORE: 0.6438

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R894S	TCGA-64-5781	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.0556
p.R894S	DO23740	LUAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.0556
p.E875D	TCGA-B5-A0JY	UCEC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.25
p.E875D	DO43041	UCEC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.25
p.E875D	SIDM01726	Ewing's Sarcoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	0.25
p.I885S	TCGA-B5-A11E	UCEC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.3056
p.I885S	DO41644	UCEC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.3056
p.I885F	TCGA-BP-4985	KIRC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.3056
p.I885F	DO20693	KIRC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.3056
p.S870A	TCGA-EO-A22X	UCEC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	0.1111
p.S870A	DO43907	UCEC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.1111
p.S891T	DO48232	ESCA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SCF_FBW7_1	4619:4625	PPTPPSS	FBXW7	0.9983	More...
Q96QT6	PHD finger protein 12	DEG_SCF_FBW7_1	878:884	PPTPPSS	FBXW7	0.8927	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SCF_FBW7_1	497:503	PPTPPSS	FBXW7	0.8747	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons