DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: DEG_SCF_FBW7_1

Location: 4619:4625

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 86.9571

COIL: 0.974

CONS_SCORE: 0.5769

DSS_SCORE: 0.7758

HELIX: 0.0107

FCONS_SCORE: 1.0756

RIG_SCORE: 0.5199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L4616P	SIDM00334	Endometrial Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	0.25
p.L4616P	ACH-000879	Endometrial/Uterine Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	0.25
p.P4620L	SIDM00602	Gastric Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	0.6471
p.P4620L	ACH-000919	Gastric Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	0.6471
p.P4620L	IM-95	stomach	COSMIC	PPTPPSS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SCF_FBW7_1	4619:4625	PPTPPSS	FBXW7	0.9983	More...
Q96QT6	PHD finger protein 12	DEG_SCF_FBW7_1	878:884	PPTPPSS	FBXW7	0.8927	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SCF_FBW7_1	497:503	PPTPPSS	FBXW7	0.8747	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons