DegronMD

Uniprot ID: Q96QT6

Source protein: PHD finger protein 12

Source gene: PHF12

Class: DEG_COP1_1

Location: 706:716

E3 ligase: COP1

DEGRON score: 0.8664

ASA_SCORE: 72.5909

COIL: 0.8396

CONS_SCORE: 0.3345

DSS_SCORE: 0.321

HELIX: 0.0495

FCONS_SCORE: 1.0748

RIG_SCORE: 0.7168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T704M	TCGA-AA-A01R	COAD	TCGA	SIGSALTVPSF	DEG_COP1_1	0.2778
p.T704M	DO7934	COAD	ICGC	SIGSALTVPSF	DEG_COP1_1	0.2778
p.V713L	TCGA-DA-A1IB	SKCM	TCGA	SIGSALTVPSF	DEG_COP1_1	0.6765
p.V713L	DO38033	SKCM	ICGC	SIGSALTVPSF	DEG_COP1_1	0.6765
p.S720F	TCGA-EO-A22X	UCEC	TCGA	SIGSALTVPSF	DEG_COP1_1	0.2222
p.S720F	DO43907	UCEC	ICGC	SIGSALTVPSF	DEG_COP1_1	0.2222
p.S706P	TCGA-EO-A3B0	UCEC	TCGA	SIGSALTVPSF	DEG_COP1_1	0.6752
p.S706P	DO219773	UCEC	ICGC	SIGSALTVPSF	DEG_COP1_1	0.6752
p.S709N	DO230312	COCA	ICGC	SIGSALTVPSF	DEG_COP1_1	0.7069
p.L726I	DO228948	LICA	ICGC	SIGSALTVPSF	DEG_COP1_1	0.0556
p.S701R	DO229027	LICA	ICGC	SIGSALTVPSF	DEG_COP1_1	0.1944
p.P702L	SIDM00057	Neuroblastoma	GDSC	SIGSALTVPSF	DEG_COP1_1	0.2222
p.P702L	ACH-000676	Brain Cancer	CCLE	SIGSALTVPSF	DEG_COP1_1	0.2222
p.P702L	ACH-002389	Neuroblastoma	CCLE	SIGSALTVPSF	DEG_COP1_1	0.2222
p.P702L	ACN	autonomic_ganglia	COSMIC	SIGSALTVPSF	DEG_COP1_1	0.2222
p.S706F	SIDM00140	Melanoma	GDSC	SIGSALTVPSF	DEG_COP1_1	0.7982
p.S706F	ACH-000968	Skin Cancer	CCLE	SIGSALTVPSF	DEG_COP1_1	0.7982
p.S706F	COLO-792	skin	COSMIC	SIGSALTVPSF	DEG_COP1_1	0.7982
p.N719K	SIDM01387	Small Cell Lung Carcinoma	GDSC	SIGSALTVPSF	DEG_COP1_1	0.25
p.N719K	ACH-000921	Lung Cancer	CCLE	SIGSALTVPSF	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QT6	PHD finger protein 12	DEG_COP1_1	706:716	SIGSALTVPSF	COP1	0.8664	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons