DegronMD

Uniprot ID: O95793

Source protein: Double-stranded RNA-binding protein Staufen homolog 1

Source gene: STAU1

Class: DEG_SCF_SKP2-CKS1_1

Location: 368:375

E3 ligase: SKP2,CSK1

DEGRON score: 0.7546

ASA_SCORE: 105.6375

COIL: 0.8621

CONS_SCORE: 0.4237

DSS_SCORE: 0.6738

HELIX: 0.0821

FCONS_SCORE: 0.931

RIG_SCORE: 0.6854

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P373S	TCGA-AP-A0LM	UCEC	TCGA	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.6752
p.K375N	TCGA-BS-A0UF	UCEC	TCGA	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.6918
p.Q358R	TCGA-D1-A15X	UCEC	TCGA	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.0556
p.M371I	DO2401	BRCA	ICGC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.7618
p.A360T	DO3542	BRCA	ICGC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.1111
p.V368I	DO220883	MELA	ICGC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.7076
p.A370T	DO222407	MELA	ICGC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.7139
p.P371L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P362L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.1667
p.G380D	HMV-II	skin	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P365L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.25
p.G382D	HMV-II	skin	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.5833
p.A384S	HT-115	large_intestine	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.0833
p.G379D	HMV-II	skin	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P363L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.6389
p.E385K	OE19	oesophagus	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.0556
p.A385S	HT-115	large_intestine	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SCF_SKP2-CKS1_1	368:375	SEEKTPIK	SKP2,CSK1	0.7546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons