DegronMD

Uniprot ID: O95793

Source protein: Double-stranded RNA-binding protein Staufen homolog 1

Source gene: STAU1

Class: DEG_SCF_FBW7_2

Location: 71:76

E3 ligase: FBXW7

DEGRON score: 0.7352

ASA_SCORE: 39.3

COIL: 0.3525

CONS_SCORE: 0.6476

DSS_SCORE: 0.2691

HELIX: 0.6197

FCONS_SCORE: 1.3084

RIG_SCORE: 0.7993

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S70R	TCGA-4Z-AA89	BLCA	TCGA	ITPTVE	DEG_SCF_FBW7_2	0.3056
p.S70R	DO218991	BLCA	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.3056
p.K86N	TCGA-A5-A2K5	UCEC	TCGA	ITPTVE	DEG_SCF_FBW7_2	0.1667
p.C81R	TCGA-AZ-4615	COAD	TCGA	ITPTVE	DEG_SCF_FBW7_2	0.1944
p.C81R	DO7977	COAD	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.1944
p.E76G	TCGA-D3-A3C8	SKCM	TCGA	ITPTVE	DEG_SCF_FBW7_2	0.7199
p.E76G	DO47636	SKCM	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.7199
p.T62I	TCGA-FA-A86F	DLBC	TCGA	ITPTVE	DEG_SCF_FBW7_2	0.0833
p.T62I	DO219892	DLBC	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.0833
p.E82V	DO49800	BLCA	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.1667
p.P85S	DO8119	COAD	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.0833
p.Q80K	DO228971	LICA	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.2222
p.K74T	DO46657	PAAD	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.7306
p.H69Y	DO37499	SKCM	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.2778
p.A68S	DO229245	THCA	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.25
p.T63I	DO41999	UCEC	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.1111
p.E82D	DO42608	UCEC	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.1667
p.D70N	DO43907	UCEC	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.3056
p.M82V	SIDM01023	Acute Myeloid Leukemia	GDSC	ITPTVE	DEG_SCF_FBW7_2	0.1667
p.M82V	SIDM00214	Colorectal Carcinoma	GDSC	ITPTVE	DEG_SCF_FBW7_2	0.1667
p.M82V	ACH-000006	Leukemia	CCLE	ITPTVE	DEG_SCF_FBW7_2	0.1667
p.M82V	ACH-000955	Colon/Colorectal Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	0.1667
p.M82V	MONO-MAC-6	haematopoietic_and_lymphoid_tissue	COSMIC	ITPTVE	DEG_SCF_FBW7_2	0.1667
p.M82V	SNU-407	large_intestine	COSMIC	ITPTVE	DEG_SCF_FBW7_2	0.1667
p.A79S	SIDM00127	Oral Cavity Carcinoma	GDSC	ITPTVE	DEG_SCF_FBW7_2	0.25
p.A79S	ACH-002250	Head and Neck Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	0.25
p.A79S	JHU-022	upper_aerodigestive_tract	COSMIC	ITPTVE	DEG_SCF_FBW7_2	0.25
p.C81F	SIDM01611	Endometrial Carcinoma	GDSC	ITPTVE	DEG_SCF_FBW7_2	0.1944
p.C81F	ACH-000996	Endometrial/Uterine Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	0.1944
p.A66E	ACH-001814	Bone Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SCF_FBW7_2	71:76	ITPTVE	FBXW7	0.7352	More...
Q9NUL3	Double-stranded RNA-binding protein Staufen homolog 2	DEG_SCF_FBW7_2	94:99	ITPTVE	FBXW7	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPTVE

Degron related mutations and impact score

Drug responses associated with STAU1 mutations

All proteins holding degron of ITPTVE