DegronMD - Q9NUL3(STAU2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E501A	TCGA-2G-AALS	TGCT	TCGA	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.0833
p.G102W	TCGA-68-7757	LUSC	TCGA	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.25
p.A479V	TCGA-A5-A1OF	UCEC	TCGA	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.1111
p.M105T	TCGA-AG-3906	READ	TCGA	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1667
p.V87A	TCGA-BG-A222	UCEC	TCGA	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1389
p.E478K	TCGA-DK-AA6R	BLCA	TCGA	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.0833
p.E478K	DO219006	BLCA	ICGC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.0833
p.R107S	TCGA-EE-A3AA	SKCM	TCGA	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1111
p.E501Q	TCGA-OR-A5KZ	ACC	TCGA	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.0833
p.M101R	DO225083	BRCA	ICGC	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.2778
p.K498N	DO3904	BRCA	ICGC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation blocking ubiquitination signal	0.6111
p.K498N	DO44275	CESC	ICGC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation blocking ubiquitination signal	0.6111
p.F477Y	DO234307	ESAD	ICGC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.0556
p.D484E	DO229045	LICA	ICGC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.25
p.P88T	DO229009	LICA	ICGC	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1667
p.R99W	DO26683	LUSC	ICGC	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation altering degron motif	0.8634
p.N486S	DO220263	SARC	ICGC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation blocking phosphorylation signal	0.75
p.P86Q	DO38033	SKCM	ICGC	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1111
p.F477V	DO41758	UCEC	ICGC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.0556
p.P493S	SIDM00845	Burkitt's Lymphoma	GDSC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.3056
p.P493S	SIDM00035	Thyroid Gland Carcinoma	GDSC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.3056
p.P493S	SIDM01519	Head and Neck Carcinoma	GDSC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation rewiring degron network	0.3056
p.P489S	SIDM00845	Burkitt's Lymphoma	GDSC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation altering degron motif	0.6752
p.P489S	SIDM00035	Thyroid Gland Carcinoma	GDSC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation altering degron motif	0.6752
p.P489S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation altering degron motif	0.6752
p.S486C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation blocking phosphorylation signal	0.75
p.S486C	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation blocking phosphorylation signal	0.75
p.S486C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PTPPCS	DEG_SCF_FBW7_1	487:492	Mutation blocking phosphorylation signal	0.75
p.I89V	ACH-000955	Colon/Colorectal Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1944
p.I89V	SNU-407	large intestine	COSMIC	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1944
p.A93V	ACH-000984	Endometrial/Uterine Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.3056
p.M95I	ACH-001991	Primary	CCLE	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation altering degron motif	0.7618
p.F89L	HT-1376	urinary tract	COSMIC	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.1944
p.P103S	MZ7-mel	skin	COSMIC	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.2222
p.P109S	MZ7-mel	skin	COSMIC	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.0556
p.F101L	HT-1376	urinary tract	COSMIC	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.2778
p.I92N	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	ITPTVE	DEG_SCF_FBW7_2	94:99	Mutation rewiring degron network	0.2778

Kaplan plot for STAU2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STAU2

UniProt ID: Q9NUL3

Entrez ID: 27067

Protein name: Double-stranded RNA-binding protein Staufen homolog 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STAU2 in