DegronMD

Uniprot ID: Q9NUL3

Source protein: Double-stranded RNA-binding protein Staufen homolog 2

Source gene: STAU2

Class: DEG_SCF_FBW7_1

Location: 487:492

E3 ligase: FBXW7

DEGRON score: 0.9891

ASA_SCORE: 86.6333

COIL: 0.955

CONS_SCORE: 0.3859

DSS_SCORE: 0.6038

HELIX: 0.0217

FCONS_SCORE: 0.8362

RIG_SCORE: 0.6131

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E501A	TCGA-2G-AALS	TGCT	TCGA	PTPPCS	DEG_SCF_FBW7_1	0.0833
p.A479V	TCGA-A5-A1OF	UCEC	TCGA	PTPPCS	DEG_SCF_FBW7_1	0.1111
p.E478K	TCGA-DK-AA6R	BLCA	TCGA	PTPPCS	DEG_SCF_FBW7_1	0.0833
p.E478K	DO219006	BLCA	ICGC	PTPPCS	DEG_SCF_FBW7_1	0.0833
p.E501Q	TCGA-OR-A5KZ	ACC	TCGA	PTPPCS	DEG_SCF_FBW7_1	0.0833
p.K498N	DO3904	BRCA	ICGC	PTPPCS	DEG_SCF_FBW7_1	0.6111
p.K498N	DO44275	CESC	ICGC	PTPPCS	DEG_SCF_FBW7_1	0.6111
p.F477Y	DO234307	ESAD	ICGC	PTPPCS	DEG_SCF_FBW7_1	0.0556
p.D484E	DO229045	LICA	ICGC	PTPPCS	DEG_SCF_FBW7_1	0.25
p.N486S	DO220263	SARC	ICGC	PTPPCS	DEG_SCF_FBW7_1	0.75
p.F477V	DO41758	UCEC	ICGC	PTPPCS	DEG_SCF_FBW7_1	0.0556
p.P493S	SIDM00845	Burkitt's Lymphoma	GDSC	PTPPCS	DEG_SCF_FBW7_1	0.3056
p.P493S	SIDM00035	Thyroid Gland Carcinoma	GDSC	PTPPCS	DEG_SCF_FBW7_1	0.3056
p.P493S	SIDM01519	Head and Neck Carcinoma	GDSC	PTPPCS	DEG_SCF_FBW7_1	0.3056
p.P489S	SIDM00845	Burkitt's Lymphoma	GDSC	PTPPCS	DEG_SCF_FBW7_1	0.6752
p.P489S	SIDM00035	Thyroid Gland Carcinoma	GDSC	PTPPCS	DEG_SCF_FBW7_1	0.6752
p.P489S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTPPCS	DEG_SCF_FBW7_1	0.6752
p.S486C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTPPCS	DEG_SCF_FBW7_1	0.75
p.S486C	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PTPPCS	DEG_SCF_FBW7_1	0.75
p.S486C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPCS	DEG_SCF_FBW7_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NUL3	Double-stranded RNA-binding protein Staufen homolog 2	DEG_SCF_FBW7_1	487:492	PTPPCS	FBXW7	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons