DegronMD

Uniprot ID: Q9NUL3

Source protein: Double-stranded RNA-binding protein Staufen homolog 2

Source gene: STAU2

Class: DEG_SCF_FBW7_2

Location: 94:99

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 67.1

COIL: 0.6995

CONS_SCORE: 0.6705

DSS_SCORE: 0.5312

HELIX: 0.1382

FCONS_SCORE: 1.3384

RIG_SCORE: 0.7427

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G102W	TCGA-68-7757	LUSC	TCGA	ITPTVE	DEG_SCF_FBW7_2	0.25
p.M105T	TCGA-AG-3906	READ	TCGA	ITPTVE	DEG_SCF_FBW7_2	0.1667
p.V87A	TCGA-BG-A222	UCEC	TCGA	ITPTVE	DEG_SCF_FBW7_2	0.1389
p.R107S	TCGA-EE-A3AA	SKCM	TCGA	ITPTVE	DEG_SCF_FBW7_2	0.1111
p.M101R	DO225083	BRCA	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.2778
p.P88T	DO229009	LICA	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.1667
p.R99W	DO26683	LUSC	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.8634
p.P86Q	DO38033	SKCM	ICGC	ITPTVE	DEG_SCF_FBW7_2	0.1111
p.I89V	ACH-000955	Colon/Colorectal Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	0.1944
p.I89V	SNU-407	large_intestine	COSMIC	ITPTVE	DEG_SCF_FBW7_2	0.1944
p.A93V	ACH-000984	Endometrial/Uterine Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	0.3056
p.M95I	ACH-001991	Primary	CCLE	ITPTVE	DEG_SCF_FBW7_2	0.7618
p.F89L	HT-1376	urinary_tract	COSMIC	ITPTVE	DEG_SCF_FBW7_2	0.1944
p.P103S	MZ7-mel	skin	COSMIC	ITPTVE	DEG_SCF_FBW7_2	0.2222
p.P109S	MZ7-mel	skin	COSMIC	ITPTVE	DEG_SCF_FBW7_2	0.0556
p.F101L	HT-1376	urinary_tract	COSMIC	ITPTVE	DEG_SCF_FBW7_2	0.2778
p.I92N	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	ITPTVE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SCF_FBW7_2	71:76	ITPTVE	FBXW7	0.7352	More...
Q9NUL3	Double-stranded RNA-binding protein Staufen homolog 2	DEG_SCF_FBW7_2	94:99	ITPTVE	FBXW7	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons