DegronMD - O15417(TNRC18)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G2105E	TCGA-12-3651	GBM	TCGA	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation rewiring degron network	0.25
p.G2105E	DO13845	GBM	ICGC	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation rewiring degron network	0.25
p.P2293T	TCGA-25-2398	OV	TCGA	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.0833
p.P2293T	DO31250	OV	ICGC	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.0833
p.L2274H	TCGA-3N-A9WC	SKCM	TCGA	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.1389
p.L2274H	DO51234	SKCM	ICGC	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.1389
p.L2274F	TCGA-3N-A9WC	SKCM	TCGA	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.1389
p.L2274F	DO51234	SKCM	ICGC	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.1389
p.R2278H	TCGA-77-8130	LUSC	TCGA	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.25
p.R2278H	DO26566	LUSC	ICGC	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.25
p.P1043L	TCGA-A6-2686	COAD	TCGA	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation altering degron motif	0.7582
p.P1043L	DO7828	COAD	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation altering degron motif	0.7582
p.A1020T	TCGA-A6-5661	COAD	TCGA	PPAY	ITCH	1018:1021	Mutation altering degron motif	0.6028
p.A1020T	DO8634	COAD	ICGC	PPAY	ITCH	1018:1021	Mutation altering degron motif	0.6028
p.E1053D	TCGA-AJ-A5DW	UCEC	TCGA	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation rewiring degron network	0.1389
p.E1053D	DO50075	UCEC	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation rewiring degron network	0.1389
p.E2536K	TCGA-AX-A0J0	UCEC	TCGA	DSGNPKS	DEG_SCF_TRCP1_1	2537:2543	Mutation rewiring degron network	0.3056
p.E2536K	DO41133	UCEC	ICGC	DSGNPKS	DEG_SCF_TRCP1_1	2537:2543	Mutation rewiring degron network	0.3056
p.R2102C	TCGA-AX-A1C9	UCEC	TCGA	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation altering degron motif	0.719
p.R2102C	DO43098	UCEC	ICGC	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation altering degron motif	0.719
p.A1051D	TCGA-B5-A1MR	UCEC	TCGA	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation rewiring degron network	0.1944
p.A1051D	DO41758	UCEC	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation rewiring degron network	0.1944
p.N2774S	TCGA-B7-5816	STAD	TCGA	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.3056
p.N2774S	DO38599	STAD	ICGC	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.3056
p.N2774S	SIDM00480	Ovarian Carcinoma	GDSC	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.3056
p.N2774S	SIDM01088	Endometrial Carcinoma	GDSC	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.3056
p.N2774S	ACH-000704	Ovarian Cancer	CCLE	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.3056
p.N2774S	ACH-000965	Endometrial/Uterine Cancer	CCLE	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.3056
p.N2774S	OAW-42	ovary	COSMIC	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.3056
p.N2774S	RL95-2	endometrium	COSMIC	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.3056
p.R2302C	TCGA-B7-5816	STAD	TCGA	SKDTGE	DEG_Kelch_Keap1_1	2308:2313	Mutation rewiring degron network	0.1667
p.R2302C	DO38599	STAD	ICGC	SKDTGE	DEG_Kelch_Keap1_1	2308:2313	Mutation rewiring degron network	0.1667
p.P1040L	TCGA-BG-A0MQ	UCEC	TCGA	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation altering degron motif	0.6471
p.P1040L	DO41127	UCEC	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation altering degron motif	0.6471
p.K2098N	TCGA-D1-A17F	UCEC	TCGA	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation altering degron motif	0.5806
p.K2098N	DO43362	UCEC	ICGC	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation altering degron motif	0.5806
p.G1092W	TCGA-D3-A2JN	SKCM	TCGA	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.0556
p.G1092W	TCGA-EE-A3AC	SKCM	TCGA	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.0556
p.G1092W	TCGA-FS-A1Z4	SKCM	TCGA	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.0556
p.G1092W	DO37631	SKCM	ICGC	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.0556
p.G1092W	DO37462	SKCM	ICGC	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.0556
p.G1092W	DO47590	SKCM	ICGC	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.0556
p.Q2287P	TCGA-DD-AAD1	LIHC	TCGA	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.25
p.Q2287P	DO52218	LIHC	ICGC	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.25
p.A2780T	TCGA-DI-A0WH	UCEC	TCGA	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.1389
p.A2780T	DO43843	UCEC	ICGC	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.1389
p.R2766Q	TCGA-EC-A24G	UCEC	TCGA	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation altering degron motif	0.7329
p.R2766Q	DO40996	UCEC	ICGC	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation altering degron motif	0.7329
p.P1043S	TCGA-EE-A2GC	SKCM	TCGA	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation altering degron motif	0.6752
p.P1043S	DO37839	SKCM	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation altering degron motif	0.6752
p.E1404D	TCGA-EK-A2PG	CESC	TCGA	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.0556
p.E1404D	DO49939	CESC	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.0556
p.E1404D	SIDM00834	Colorectal Carcinoma	GDSC	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.0556
p.R2102H	TCGA-EO-A22R	UCEC	TCGA	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation altering degron motif	0.7133
p.R2102H	DO42713	UCEC	ICGC	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation altering degron motif	0.7133
p.R2775W	TCGA-EO-A22U	UCEC	TCGA	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.2778
p.R2775W	DO43755	UCEC	ICGC	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.2778
p.A2779T	TCGA-FI-A2D0	UCEC	TCGA	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.1667
p.A2779T	DO43891	UCEC	ICGC	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation rewiring degron network	0.1667
p.R1410Q	TCGA-FI-A2D5	UCEC	TCGA	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.2222
p.R1410Q	DO41331	UCEC	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.2222
p.L2279I	TCGA-HU-A4H4	STAD	TCGA	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.2778
p.L2279I	DO47721	STAD	ICGC	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.2778
p.P1070L	TCGA-WE-A8ZT	SKCM	TCGA	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.0833
p.P1070L	DO51290	SKCM	ICGC	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.0833
p.L1074M	TCGA-XK-AAIW	PRAD	TCGA	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.1944
p.L1074M	DO51407	PRAD	ICGC	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.1944
p.F1071L	TCGA-ZF-AA4X	BLCA	TCGA	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.1111
p.F1071L	DO219091	BLCA	ICGC	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.1111
p.A1411S	DO222404	BTCA	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.25
p.R1415W	DO233136	GACA	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation altering degron motif	0.8634
p.F2535L	DO229029	LICA	ICGC	DSGNPKS	DEG_SCF_TRCP1_1	2537:2543	Mutation rewiring degron network	0.2778
p.A1423E	DO229036	LICA	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.3056
p.P1040S	DO230937	LUSC	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation altering degron motif	0.5641
p.P1040S	DO224619	LUSC	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation altering degron motif	0.5641
p.P2541R	DO26710	LUSC	ICGC	DSGNPKS	DEG_SCF_TRCP1_1	2537:2543	Mutation altering degron motif	0.6401
p.V1015M	DO228891	MALY	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.25
p.S2626F	DO220878	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	2612:2616	Mutation blocking phosphorylation signal	0.5
p.G1425S	DO222837	MELA	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.25
p.A1414P	DO31729	OV	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation altering degron motif	0.6392
p.R2278L	DO35568	PBCA	ICGC	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.25
p.P1039S	DO229479	SKCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation altering degron motif	0.6752
p.A1025P	DO229133	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.2222
p.A1025P	DO229140	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.2222
p.A1025P	DO229148	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.2222
p.A1025P	DO229092	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.2222
p.S1029P	DO229148	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation rewiring degron network	0.0556
p.S1029P	DO229148	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.1111
p.T1026P	DO229148	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.1944
p.T1026P	DO229180	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.1944
p.T1026P	DO229191	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.1944
p.T1026P	DO229121	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.1944
p.T1026P	DO229085	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.1944
p.T1032P	DO229180	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation blocking phosphorylation signal	0.5833
p.T1032P	DO229191	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation blocking phosphorylation signal	0.5833
p.T1032P	DO229095	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation blocking phosphorylation signal	0.5833
p.S1028R	DO229180	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.1389
p.S1028R	DO229191	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.1389
p.S1028R	DO229095	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.1389
p.S1033R	DO229181	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation blocking phosphorylation signal	0.6111
p.S1033R	DO229085	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation blocking phosphorylation signal	0.6111
p.H1030P	DO229191	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation rewiring degron network	0.0833
p.H1030P	DO229191	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.0833
p.H1030P	DO229199	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation rewiring degron network	0.0833
p.H1030P	DO229199	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.0833
p.H1030P	DO229085	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation rewiring degron network	0.0833
p.H1030P	DO229085	THCA	ICGC	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.0833
p.K2089N	DO229275	THCA	ICGC	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation substituting flanking lysine	0.1944
p.G1425V	DO229229	THCA	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.25
p.G1425V	ACH-000871	Lung Cancer	CCLE	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.25
p.S2614A	DO229232	THCA	ICGC	PASSS	DEG_SPOP_SBC_1	2612:2616	Mutation altering degron motif	0.7588
p.K2301T	DO229234	THCA	ICGC	SKDTGE	DEG_Kelch_Keap1_1	2308:2313	Mutation substituting flanking lysine	0.25
p.G2321E	DO42673	UCEC	ICGC	SKDTGE	DEG_Kelch_Keap1_1	2308:2313	Mutation rewiring degron network	0.1111
p.G2530V	SIDM02026	Colorectal Carcinoma	GDSC	DSGNPKS	DEG_SCF_TRCP1_1	2537:2543	Mutation rewiring degron network	0.1389
p.G2321W	SIDM02034	Colorectal Carcinoma	GDSC	SKDTGE	DEG_Kelch_Keap1_1	2308:2313	Mutation rewiring degron network	0.1111
p.P2273L	SIDM00086	Kidney Carcinoma	GDSC	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.1111
p.P2273L	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.1111
p.P2273L	SIDM00225	Melanoma	GDSC	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.1111
p.S2603I	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	2612:2616	Mutation rewiring degron network	0.0833
p.S2603I	ACH-000510	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	2612:2616	Mutation rewiring degron network	0.0833
p.T2319M	SIDM00889	Cervical Carcinoma	GDSC	SKDTGE	DEG_Kelch_Keap1_1	2308:2313	Mutation blocking phosphorylation signal	0.6111
p.H1090R	SIDM00445	Esophageal Carcinoma	GDSC	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.1111
p.G2103S	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation rewiring degron network	0.3056
p.G2103S	ACH-000611	Lymphoma	CCLE	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation rewiring degron network	0.3056
p.G2103S	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation rewiring degron network	0.3056
p.A1408V	SIDM00429	B-Lymphoblastic Leukemia	GDSC	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.1667
p.K2315R	SIDM00951	T-Lymphoblastic Leukemia	GDSC	SKDTGE	DEG_Kelch_Keap1_1	2308:2313	Mutation rewiring degron network	0.2778
p.K2315R	ACH-002222	Leukemia	CCLE	SKDTGE	DEG_Kelch_Keap1_1	2308:2313	Mutation rewiring degron network	0.2778
p.K2315R	CTV-1	haematopoietic and lymphoid tissue	COSMIC	SKDTGE	DEG_Kelch_Keap1_1	2308:2313	Mutation rewiring degron network	0.2778
p.P1070A	SIDM00150	Colorectal Carcinoma	GDSC	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.0833
p.P1070A	ACH-000969	Colon/Colorectal Cancer	CCLE	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.0833
p.P1070A	KM12	large intestine	COSMIC	PPRY	ITCH	1079:1082	Mutation rewiring degron network	0.0833
p.E1053K	SIDM01611	Endometrial Carcinoma	GDSC	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation rewiring degron network	0.1389
p.E1053K	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation rewiring degron network	0.1389
p.A1025T	ACH-000348	Skin Cancer	CCLE	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.2222
p.E1409K	ACH-000481	Lung Cancer	CCLE	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation rewiring degron network	0.1944
p.P1024L	ACH-000835	Sarcoma	CCLE	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.25
p.M2112I	ACH-000851	Lung Cancer	CCLE	KKENR	DEG_APCC_KENBOX_2	2098:2102	Mutation rewiring degron network	0.0556
p.A2604S	ACH-000906	Ovarian Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	2612:2616	Mutation rewiring degron network	0.1111
p.S2603R	ACH-000906	Ovarian Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	2612:2616	Mutation rewiring degron network	0.0833
p.R2768H	ACH-000928	Endometrial/Uterine Cancer	CCLE	KRQRLPSVE	DEG_APCC_DBOX_1	2765:2773	Mutation altering degron motif	0.7133
p.R2278C	ACH-001369	Ovarian Cancer	CCLE	PPDY	ITCH	2281:2284	Mutation rewiring degron network	0.25
p.E1050K	ACH-001414	Bladder Cancer	CCLE	PPPTPGIT	DEG_SCF_FBW7_1	1039:1046	Mutation rewiring degron network	0.2222
p.P1027S	ACH-001638	Lymphoma	CCLE	PPAY	ITCH	1018:1021	Mutation rewiring degron network	0.1667
p.K2309R	ACH-001685	Lymphoma	CCLE	SKDTGE	DEG_Kelch_Keap1_1	2308:2313	Mutation altering degron motif	0.6126
p.G2530R	ACH-001852	Bile Duct Cancer	CCLE	DSGNPKS	DEG_SCF_TRCP1_1	2537:2543	Mutation rewiring degron network	0.1389
p.A1414V	ACH-002800	Unknown	CCLE	ARPSLESLL	DEG_APCC_DBOX_1	1414:1422	Mutation altering degron motif	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNRC18

UniProt ID: O15417

Entrez ID: 84629

Protein name: Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNRC18 in