DegronMD

Uniprot ID: O15417

Source protein: Trinucleotide repeat-containing gene 18 protein

Source gene: TNRC18

Class: DEG_SCF_TRCP1_1

Location: 2537:2543

E3 ligase: BTRC

DEGRON score: 0.9853

ASA_SCORE: 77.9286

COIL: 0.9269

CONS_SCORE: 0.3396

DSS_SCORE: 0.8499

HELIX: 0.0291

FCONS_SCORE: 0.8525

RIG_SCORE: 0.5502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2536K	TCGA-AX-A0J0	UCEC	TCGA	DSGNPKS	DEG_SCF_TRCP1_1	0.3056
p.E2536K	DO41133	UCEC	ICGC	DSGNPKS	DEG_SCF_TRCP1_1	0.3056
p.F2535L	DO229029	LICA	ICGC	DSGNPKS	DEG_SCF_TRCP1_1	0.2778
p.P2541R	DO26710	LUSC	ICGC	DSGNPKS	DEG_SCF_TRCP1_1	0.6401
p.G2530V	SIDM02026	Colorectal Carcinoma	GDSC	DSGNPKS	DEG_SCF_TRCP1_1	0.1389
p.G2530R	ACH-001852	Bile Duct Cancer	CCLE	DSGNPKS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15417	Trinucleotide repeat-containing gene 18 protein	DEG_SCF_TRCP1_1	2537:2543	DSGNPKS	BTRC	0.9853	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons