DegronMD

Uniprot ID: O15417

Source protein: Trinucleotide repeat-containing gene 18 protein

Source gene: TNRC18

Class: ITCH

Location: 1018:1021

E3 ligase: ITCH,NEDD4

DEGRON score: 0.98

ASA_SCORE: 96.6

COIL: 0.9248

CONS_SCORE: 0.3806

DSS_SCORE: 0.5615

HELIX: 0.0378

FCONS_SCORE: 1.0691

RIG_SCORE: 0.6383

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1020T	TCGA-A6-5661	COAD	TCGA	PPAY	ITCH	0.6028
p.A1020T	DO8634	COAD	ICGC	PPAY	ITCH	0.6028
p.V1015M	DO228891	MALY	ICGC	PPAY	ITCH	0.25
p.P1024L	ACH-000835	Sarcoma	CCLE	PPAY	ITCH	0.25
p.A1025P	DO229133	THCA	ICGC	PPAY	ITCH	0.2222
p.A1025P	DO229140	THCA	ICGC	PPAY	ITCH	0.2222
p.A1025P	DO229148	THCA	ICGC	PPAY	ITCH	0.2222
p.A1025P	DO229092	THCA	ICGC	PPAY	ITCH	0.2222
p.A1025T	ACH-000348	Skin Cancer	CCLE	PPAY	ITCH	0.2222
p.T1026P	DO229148	THCA	ICGC	PPAY	ITCH	0.1944
p.T1026P	DO229180	THCA	ICGC	PPAY	ITCH	0.1944
p.T1026P	DO229191	THCA	ICGC	PPAY	ITCH	0.1944
p.T1026P	DO229121	THCA	ICGC	PPAY	ITCH	0.1944
p.T1026P	DO229085	THCA	ICGC	PPAY	ITCH	0.1944
p.P1027S	ACH-001638	Lymphoma	CCLE	PPAY	ITCH	0.1667
p.S1028R	DO229180	THCA	ICGC	PPAY	ITCH	0.1389
p.S1028R	DO229191	THCA	ICGC	PPAY	ITCH	0.1389
p.S1028R	DO229095	THCA	ICGC	PPAY	ITCH	0.1389
p.S1029P	DO229148	THCA	ICGC	PPAY	ITCH	0.1111
p.H1030P	DO229191	THCA	ICGC	PPAY	ITCH	0.0833
p.H1030P	DO229199	THCA	ICGC	PPAY	ITCH	0.0833
p.H1030P	DO229085	THCA	ICGC	PPAY	ITCH	0.0833

Showing 1 to 22 of 22 entries

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Drug responses associated with TNRC18 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPAY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07912	Activated CDC42 kinase 1	ITCH	632:635	PPAY	ITCH,NEDD4	0.9991	More...
P37088	Amiloride-sensitive sodium channel subunit alpha	ITCH	641:644	PPAY	ITCH,NEDD4	0.9695	More...
O14497	AT-rich interactive domain-containing protein 1A	ITCH	145:148	PPAY	ITCH,NEDD4	0.9015	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	ITCH	843:846	PPAY	ITCH,NEDD4	0.9548	More...
Q99700	Ataxin-2	ITCH	1031:1034	PPAY	ITCH,NEDD4	0.991	More...
O95415	Brain protein I3	ITCH	11:14	PPAY	ITCH,NEDD4	0.9941	More...
O75952	Calcium-binding tyrosine phosphorylation-regulated protein	ITCH	270:273	PPAY	ITCH,NEDD4	0.9464	More...
Q8NFW1	Collagen alpha-1	ITCH	1488:1491	PPAY	ITCH,NEDD4	0.9918	More...
Q9NWM3	CUE domain-containing protein 1	ITCH	133:136	PPAY	ITCH,NEDD4	0.993	More...
Q8IV13	Cyclin-J-like protein	ITCH	330:333	PPAY	ITCH,NEDD4	0.9938	More...
O75909	Cyclin-K	ITCH	462:465	PPAY	ITCH,NEDD4	0.5914	More...
Q15038	DAZ-associated protein 2	ITCH	39:42	PPAY	ITCH,NEDD4	0.9779	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	ITCH	1046:1049	PPAY	ITCH,NEDD4	0.6799	More...
P18146	Early growth response protein 1	ITCH	237:240	PPAY	ITCH,NEDD4	0.9972	More...
A6NMB9	Fidgetin-like protein 2	ITCH	415:418	PPAY	ITCH,NEDD4	0.9107	More...
Q8N144	Gap junction delta-3 protein	ITCH	262:265	PPAY	ITCH,NEDD4	0.9919	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	781:784	PPAY	ITCH,NEDD4	0.9594	More...
A6NMT0	Homeobox protein DBX1	ITCH	50:53	PPAY	ITCH,NEDD4	0.9932	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	ITCH	156:159	PPAY	ITCH,NEDD4	0.9989	More...
Q96JM7	Lethal	ITCH	84:87	PPAY	ITCH,NEDD4	0.8976	More...
O43561	Linker for activation of T-cells family member 1	ITCH	61:64	PPAY	ITCH,NEDD4	0.9978	More...
Q16655	Melanoma antigen recognized by T-cells 1	ITCH	101:104	PPAY	ITCH,NEDD4	0.9993	More...
O75121	Microfibrillar-associated protein 3-like	ITCH	384:387	PPAY	ITCH,NEDD4	0.9598	More...
Q15797	Mothers against decapentaplegic homolog 1	ITCH	224:227	PPAY	ITCH,NEDD4	0.9965	More...
Q99717	Mothers against decapentaplegic homolog 5	ITCH	223:226	PPAY	ITCH,NEDD4	0.9821	More...

Showing 1 to 25 of 64 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPAY

Degron related mutations and impact score

Drug responses associated with TNRC18 mutations

All proteins holding degron of PPAY