DegronMD - Q12809(KCNH2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1084T	TCGA-44-6774	LUAD	TCGA	PTSTS	DEG_SPOP_SBC_1	1088:1092	Mutation rewiring degron network	0.2222
p.P1084T	TCGA-44-6774	LUAD	TCGA	PPAY	ITCH	1075:1078	Mutation rewiring degron network	0.1667
p.P1084Q	TCGA-46-3768	LUSC	TCGA	PTSTS	DEG_SPOP_SBC_1	1088:1092	Mutation rewiring degron network	0.2222
p.P1084Q	TCGA-46-3768	LUSC	TCGA	PPAY	ITCH	1075:1078	Mutation rewiring degron network	0.1667
p.L1094M	TCGA-AM-5820	COAD	TCGA	PTSTS	DEG_SPOP_SBC_1	1088:1092	Mutation rewiring degron network	0.2778
p.A1077T	TCGA-AP-A0LG	UCEC	TCGA	PPAY	ITCH	1075:1078	Mutation altering degron motif	0.6028
p.V1097I	TCGA-D3-A2JN	SKCM	TCGA	PTSTS	DEG_SPOP_SBC_1	1088:1092	Mutation rewiring degron network	0.1944
p.P1096L	TCGA-DF-A2KU	UCEC	TCGA	PTSTS	DEG_SPOP_SBC_1	1088:1092	Mutation rewiring degron network	0.2222
p.P1084L	TCGA-W5-AA34	CHOL	TCGA	PTSTS	DEG_SPOP_SBC_1	1088:1092	Mutation rewiring degron network	0.2222
p.P1084L	TCGA-W5-AA34	CHOL	TCGA	PPAY	ITCH	1075:1078	Mutation rewiring degron network	0.1667
p.P1084L	SIDM01210	Glioblastoma	GDSC	PTSTS	DEG_SPOP_SBC_1	1088:1092	Mutation rewiring degron network	0.2222
p.P1084L	SIDM01210	Glioblastoma	GDSC	PPAY	ITCH	1075:1078	Mutation rewiring degron network	0.1667
p.P1084L	ACH-000479	Brain Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	1088:1092	Mutation rewiring degron network	0.2222
p.P1084L	ACH-000479	Brain Cancer	CCLE	PPAY	ITCH	1075:1078	Mutation rewiring degron network	0.1667
p.P1084L	ACH-002259	Brain Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	1088:1092	Mutation rewiring degron network	0.2222
p.P1084L	ACH-002259	Brain Cancer	CCLE	PPAY	ITCH	1075:1078	Mutation rewiring degron network	0.1667
p.P1084L	KNS-81-FD	central nervous system	COSMIC	PTSTS	DEG_SPOP_SBC_1	1088:1092	Mutation rewiring degron network	0.2222
p.P1084L	KNS-81-FD	central nervous system	COSMIC	PPAY	ITCH	1075:1078	Mutation rewiring degron network	0.1667
p.L1073M	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	1075:1078	Mutation rewiring degron network	0.2778
p.L1073M	ACH-000924	Lung Cancer	CCLE	PPAY	ITCH	1075:1078	Mutation rewiring degron network	0.2778
p.L1073M	NCI-H2172	lung	COSMIC	PPAY	ITCH	1075:1078	Mutation rewiring degron network	0.2778

Kaplan plot for KCNH2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNH2

UniProt ID: Q12809

Entrez ID: 3757

Protein name: Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNH2 in