DegronMD

Uniprot ID: Q12809

Source protein: Potassium voltage-gated channel subfamily H member 2

Source gene: KCNH2

Class: DEG_SPOP_SBC_1

Location: 1088:1092

E3 ligase: SPOP

DEGRON score: 0.9344

ASA_SCORE: 93.52

COIL: 0.9636

CONS_SCORE: 0.2921

DSS_SCORE: 0.5818

HELIX: 0.0134

FCONS_SCORE: 0.9019

RIG_SCORE: 0.6146

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1084T	TCGA-44-6774	LUAD	TCGA	PTSTS	DEG_SPOP_SBC_1	0.2222
p.P1084Q	TCGA-46-3768	LUSC	TCGA	PTSTS	DEG_SPOP_SBC_1	0.2222
p.L1094M	TCGA-AM-5820	COAD	TCGA	PTSTS	DEG_SPOP_SBC_1	0.2778
p.V1097I	TCGA-D3-A2JN	SKCM	TCGA	PTSTS	DEG_SPOP_SBC_1	0.1944
p.P1096L	TCGA-DF-A2KU	UCEC	TCGA	PTSTS	DEG_SPOP_SBC_1	0.2222
p.P1084L	TCGA-W5-AA34	CHOL	TCGA	PTSTS	DEG_SPOP_SBC_1	0.2222
p.P1084L	SIDM01210	Glioblastoma	GDSC	PTSTS	DEG_SPOP_SBC_1	0.2222
p.P1084L	ACH-000479	Brain Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.2222
p.P1084L	ACH-002259	Brain Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.2222
p.P1084L	KNS-81-FD	central_nervous_system	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1764:1768	PTSTS	SPOP	0.7279	More...
Q12809	Potassium voltage-gated channel subfamily H member 2	DEG_SPOP_SBC_1	1088:1092	PTSTS	SPOP	0.9344	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	181:185	PTSTS	SPOP	0.9991	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	712:716	PTSTS	SPOP	0.9904	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	888:892	PTSTS	SPOP	0.9366	More...
Q6ZMT4	Lysine-specific demethylase 7A	DEG_SPOP_SBC_1	725:729	PTSTS	SPOP	0.964	More...
Q70CQ2	Ubiquitin carboxyl-terminal hydrolase 34	DEG_SPOP_SBC_1	3382:3386	PTSTS	SPOP	0.9803	More...
Q8N5H7	SH2 domain-containing protein 3C	DEG_SPOP_SBC_1	378:382	PTSTS	SPOP	0.9446	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	1838:1842	PTSTS	SPOP	0.8657	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	516:520	PTSTS	SPOP	0.9952	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	200:204	PTSTS	SPOP	0.9952	More...
Q9Y580	RNA-binding protein 7	DEG_SPOP_SBC_1	109:113	PTSTS	SPOP	0.9723	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	113:117	PTSTS	SPOP	0.996	More...
A8MVS5	Protein HIDE1	DEG_SPOP_SBC_1	211:215	PTSTS	SPOP	0.9885	More...
Q9UHA2	SS18-like protein 2	DEG_SPOP_SBC_1	69:73	PTSTS	SPOP	0.905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons