FUNCTION: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (Pub...
FUNCTION: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (PubMed:20023638, PubMed:20622853). Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3 (PubMed:20023638). Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (PubMed:20622853). {ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20622853}.
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GO - Biological processes (BP):
chromatin organization [GO:0006325]; histone H3-K27 demethylation [GO:0071557]; histone H3-K36 demethylation [GO:0070544]; histone H3-K9 demethylation [GO:0033169]; histone H4-K20 demethylation [GO:0035574]; midbrain development [GO:0030901]; positive regulation of transcription, DNA-templated [GO:0...
chromatin organization [GO:0006325]; histone H3-K27 demethylation [GO:0071557]; histone H3-K36 demethylation [GO:0070544]; histone H3-K9 demethylation [GO:0033169]; histone H4-K20 demethylation [GO:0035574]; midbrain development [GO:0030901]; positive regulation of transcription, DNA-templated [GO:0045893]; protein demethylation [GO:0006482]; regulation of transcription by RNA polymerase II [GO:0006357]
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GO - Molecular function (MF):
2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone demethylase activity [GO:0032452]; histone H3-di/monomethyl-lysine-9 demethylase activity [GO:0140683]; histone H3-methyl-lysine-36 demethylase activity [GO:0051864]; histone H3-methyl-lysine-9 demethylase activity [GO:0032454]; his...
2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone demethylase activity [GO:0032452]; histone H3-di/monomethyl-lysine-9 demethylase activity [GO:0140683]; histone H3-methyl-lysine-36 demethylase activity [GO:0051864]; histone H3-methyl-lysine-9 demethylase activity [GO:0032454]; histone H3-tri/di-methyl-lysine-27 demethylase activity [GO:0071558]; histone H4-methyl-lysine-20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]
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GO - Cellular component (CC):
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
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