DegronMD

Uniprot ID: Q6ZMT4

Source protein: Lysine-specific demethylase 7A

Source gene: KDM7A

Class: DEG_SCF_TRCP1_1

Location: 664:670

E3 ligase: BTRC

DEGRON score: 0.998

ASA_SCORE: 76.6286

COIL: 0.8

CONS_SCORE: 0.3413

DSS_SCORE: 0.5641

HELIX: 0.1561

FCONS_SCORE: 1.0374

RIG_SCORE: 0.6504

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I675V	TCGA-D6-A6EK	HNSC	TCGA	DSGPECT	DEG_SCF_TRCP1_1	0.1944
p.G655E	SIDM00129	Melanoma	GDSC	DSGPECT	DEG_SCF_TRCP1_1	0.0833
p.G655E	G-MEL	skin	COSMIC	DSGPECT	DEG_SCF_TRCP1_1	0.0833
p.E663A	SIDM00193	Colorectal Carcinoma	GDSC	DSGPECT	DEG_SCF_TRCP1_1	0.3056
p.E663A	SNU-81	large_intestine	COSMIC	DSGPECT	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMT4	Lysine-specific demethylase 7A	DEG_SCF_TRCP1_1	664:670	DSGPECT	BTRC	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons