DegronMD

Uniprot ID: Q92908

Source protein: Transcription factor GATA-6

Source gene: GATA6

Class: DEG_SPOP_SBC_1

Location: 516:520

E3 ligase: SPOP

DEGRON score: 0.9952

ASA_SCORE: 98.84

COIL: 0.9728

CONS_SCORE: 0.4549

DSS_SCORE: 0.6369

HELIX: 0.0138

FCONS_SCORE: 1.1449

RIG_SCORE: 0.5915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N529K	TCGA-12-0688	GBM	TCGA	PTSTS	DEG_SPOP_SBC_1	0.0833
p.N529K	DO11088	GBM	ICGC	PTSTS	DEG_SPOP_SBC_1	0.0833
p.N529K	SIDM00193	Colorectal Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	0.0833
p.N529K	ACH-000991	Colon/Colorectal Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.0833
p.N529K	SNU-81	large_intestine	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.0833
p.N529H	TCGA-64-1679	LUAD	TCGA	PTSTS	DEG_SPOP_SBC_1	0.0833
p.N529H	DO26200	LUAD	ICGC	PTSTS	DEG_SPOP_SBC_1	0.0833
p.P516L	TCGA-64-5781	LUAD	TCGA	PTSTS	DEG_SPOP_SBC_1	0.7582
p.P516L	DO23740	LUAD	ICGC	PTSTS	DEG_SPOP_SBC_1	0.7582
p.S520C	TCGA-FD-A3SS	BLCA	TCGA	PTSTS	DEG_SPOP_SBC_1	0.7541
p.S520C	DO737	BLCA	ICGC	PTSTS	DEG_SPOP_SBC_1	0.7541
p.D525N	DO222838	BTCA	ICGC	PTSTS	DEG_SPOP_SBC_1	0.1944
p.T517A	DO233766	GACA	ICGC	PTSTS	DEG_SPOP_SBC_1	0.6028
p.T517I	ACH-001389	Breast Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1764:1768	PTSTS	SPOP	0.7279	More...
Q12809	Potassium voltage-gated channel subfamily H member 2	DEG_SPOP_SBC_1	1088:1092	PTSTS	SPOP	0.9344	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	181:185	PTSTS	SPOP	0.9991	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	712:716	PTSTS	SPOP	0.9904	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	888:892	PTSTS	SPOP	0.9366	More...
Q6ZMT4	Lysine-specific demethylase 7A	DEG_SPOP_SBC_1	725:729	PTSTS	SPOP	0.964	More...
Q70CQ2	Ubiquitin carboxyl-terminal hydrolase 34	DEG_SPOP_SBC_1	3382:3386	PTSTS	SPOP	0.9803	More...
Q8N5H7	SH2 domain-containing protein 3C	DEG_SPOP_SBC_1	378:382	PTSTS	SPOP	0.9446	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	1838:1842	PTSTS	SPOP	0.8657	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	516:520	PTSTS	SPOP	0.9952	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	200:204	PTSTS	SPOP	0.9952	More...
Q9Y580	RNA-binding protein 7	DEG_SPOP_SBC_1	109:113	PTSTS	SPOP	0.9723	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	113:117	PTSTS	SPOP	0.996	More...
A8MVS5	Protein HIDE1	DEG_SPOP_SBC_1	211:215	PTSTS	SPOP	0.9885	More...
Q9UHA2	SS18-like protein 2	DEG_SPOP_SBC_1	69:73	PTSTS	SPOP	0.905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons