DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PTSTS
Uniprot ID:
Q70CQ2
Source protein:
Ubiquitin carboxyl-terminal hydrolase 34
Source gene:
USP34
Class:
DEG_SPOP_SBC_1
Location:
3382:3386
E3 ligase:
SPOP
DEGRON score:
0.9803
ASA_SCORE:
92.64
COIL:
0.9386
CONS_SCORE:
0.2583
DSS_SCORE:
0.6869
HELIX:
0.0284
FCONS_SCORE:
0.9701
RIG_SCORE:
0.6437
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D3387E
DO228976
LICA
ICGC
PTSTS
DEG_SPOP_SBC_1
0.3056
p.T3383M
SIDM01721
Non-Cancerous
GDSC
PTSTS
DEG_SPOP_SBC_1
0.6312
Drug responses associated with USP34 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P35658
Nuclear pore complex protein Nup214
DEG_SPOP_SBC_1
1764:1768
PTSTS
SPOP
0.7279
More...
Q12809
Potassium voltage-gated channel subfamily H member 2
DEG_SPOP_SBC_1
1088:1092
PTSTS
SPOP
0.9344
More...
Q14140
SERTA domain-containing protein 2
DEG_SPOP_SBC_1
181:185
PTSTS
SPOP
0.9991
More...
Q5VT52
Regulation of nuclear pre-mRNA domain-containing protein 2
DEG_SPOP_SBC_1
712:716
PTSTS
SPOP
0.9904
More...
Q659C4
La-related protein 1B
DEG_SPOP_SBC_1
888:892
PTSTS
SPOP
0.9366
More...
Q6ZMT4
Lysine-specific demethylase 7A
DEG_SPOP_SBC_1
725:729
PTSTS
SPOP
0.964
More...
Q70CQ2
Ubiquitin carboxyl-terminal hydrolase 34
DEG_SPOP_SBC_1
3382:3386
PTSTS
SPOP
0.9803
More...
Q8N5H7
SH2 domain-containing protein 3C
DEG_SPOP_SBC_1
378:382
PTSTS
SPOP
0.9446
More...
Q8NEZ4
Histone-lysine N-methyltransferase 2C
DEG_SPOP_SBC_1
1838:1842
PTSTS
SPOP
0.8657
More...
Q92908
Transcription factor GATA-6
DEG_SPOP_SBC_1
516:520
PTSTS
SPOP
0.9952
More...
Q9H4Z2
Zinc finger protein 335
DEG_SPOP_SBC_1
200:204
PTSTS
SPOP
0.9952
More...
Q9Y580
RNA-binding protein 7
DEG_SPOP_SBC_1
109:113
PTSTS
SPOP
0.9723
More...
Q86UB2
Basic immunoglobulin-like variable motif-containing protein
DEG_SPOP_SBC_1
113:117
PTSTS
SPOP
0.996
More...
A8MVS5
Protein HIDE1
DEG_SPOP_SBC_1
211:215
PTSTS
SPOP
0.9885
More...
Q9UHA2
SS18-like protein 2
DEG_SPOP_SBC_1
69:73
PTSTS
SPOP
0.905
More...