DegronMD

Uniprot ID: Q5VT52

Source protein: Regulation of nuclear pre-mRNA domain-containing protein 2

Source gene: RPRD2

Class: DEG_SPOP_SBC_1

Location: 712:716

E3 ligase: SPOP

DEGRON score: 0.9904

ASA_SCORE: 82.16

COIL: 0.9364

CONS_SCORE: 0.3777

DSS_SCORE: 0.7575

HELIX: 0.0234

FCONS_SCORE: 1.0162

RIG_SCORE: 0.5862

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T713A	TCGA-B5-A5OC	UCEC	TCGA	PTSTS	DEG_SPOP_SBC_1	0.6028
p.Q709K	TCGA-HE-7129	KIRP	TCGA	PTSTS	DEG_SPOP_SBC_1	0.25
p.D721N	TCGA-XF-A8HD	BLCA	TCGA	PTSTS	DEG_SPOP_SBC_1	0.1944
p.R703L	DO26456	LUSC	ICGC	PTSTS	DEG_SPOP_SBC_1	0.0833
p.S725F	DO220903	MELA	ICGC	PTSTS	DEG_SPOP_SBC_1	0.0833
p.R703Q	DO47739	STAD	ICGC	PTSTS	DEG_SPOP_SBC_1	0.0833
p.E702Q	SIDM00633	Breast Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	0.0556
p.E702Q	ACH-000759	Breast Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.0556
p.E702Q	MDA-MB-175-VII	breast	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.0556
p.G722E	SIDM00633	Breast Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	0.1667
p.G722E	ACH-000759	Breast Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.1667
p.G722E	MDA-MB-175-VII	breast	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.1667
p.R710H	SIDM00511	Small Cell Lung Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	0.2778
p.E702K	SIDM00252	Biliary Tract Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	0.0556
p.E702K	ACH-001861	Gallbladder Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.0556
p.E702K	TGBC1TKB	biliary_tract	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1764:1768	PTSTS	SPOP	0.7279	More...
Q12809	Potassium voltage-gated channel subfamily H member 2	DEG_SPOP_SBC_1	1088:1092	PTSTS	SPOP	0.9344	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	181:185	PTSTS	SPOP	0.9991	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	712:716	PTSTS	SPOP	0.9904	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	888:892	PTSTS	SPOP	0.9366	More...
Q6ZMT4	Lysine-specific demethylase 7A	DEG_SPOP_SBC_1	725:729	PTSTS	SPOP	0.964	More...
Q70CQ2	Ubiquitin carboxyl-terminal hydrolase 34	DEG_SPOP_SBC_1	3382:3386	PTSTS	SPOP	0.9803	More...
Q8N5H7	SH2 domain-containing protein 3C	DEG_SPOP_SBC_1	378:382	PTSTS	SPOP	0.9446	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	1838:1842	PTSTS	SPOP	0.8657	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	516:520	PTSTS	SPOP	0.9952	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	200:204	PTSTS	SPOP	0.9952	More...
Q9Y580	RNA-binding protein 7	DEG_SPOP_SBC_1	109:113	PTSTS	SPOP	0.9723	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	113:117	PTSTS	SPOP	0.996	More...
A8MVS5	Protein HIDE1	DEG_SPOP_SBC_1	211:215	PTSTS	SPOP	0.9885	More...
Q9UHA2	SS18-like protein 2	DEG_SPOP_SBC_1	69:73	PTSTS	SPOP	0.905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons