DegronMD

Uniprot ID: Q8N5H7

Source protein: SH2 domain-containing protein 3C

Source gene: SH2D3C

Class: DEG_SPOP_SBC_1

Location: 378:382

E3 ligase: SPOP

DEGRON score: 0.9446

ASA_SCORE: 72.54

COIL: 0.852

CONS_SCORE: 0.455

DSS_SCORE: 0.6616

HELIX: 0.0494

FCONS_SCORE: 1.0178

RIG_SCORE: 0.6562

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D375Y	TCGA-86-6851	LUAD	TCGA	PTSTS	DEG_SPOP_SBC_1	0.25
p.R373C	TCGA-AP-A1DK	UCEC	TCGA	PTSTS	DEG_SPOP_SBC_1	0.1944
p.R373C	SIDM00537	Colorectal Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	0.1944
p.R373C	ACH-000982	Colon/Colorectal Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.1944
p.R373C	ACH-001345	Colon/Colorectal Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.1944
p.R373C	GP5d	large_intestine	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.1944
p.L375I	DO11878	GBM	ICGC	PTSTS	DEG_SPOP_SBC_1	0.25
p.G379D	DO26444	LUSC	ICGC	PTSTS	DEG_SPOP_SBC_1	0.7198
p.G379D	DO41572	UCEC	ICGC	PTSTS	DEG_SPOP_SBC_1	0.7198
p.P374H	DO45431	LUSC	ICGC	PTSTS	DEG_SPOP_SBC_1	0.2222
p.G376R	DO220877	MELA	ICGC	PTSTS	DEG_SPOP_SBC_1	0.2778
p.P385S	DO222363	MELA	ICGC	PTSTS	DEG_SPOP_SBC_1	0.25
p.P385L	DO222683	MELA	ICGC	PTSTS	DEG_SPOP_SBC_1	0.25
p.P385L	DO37417	SKCM	ICGC	PTSTS	DEG_SPOP_SBC_1	0.25
p.G372E	DO37406	SKCM	ICGC	PTSTS	DEG_SPOP_SBC_1	0.1667
p.P370S	DO37432	SKCM	ICGC	PTSTS	DEG_SPOP_SBC_1	0.2222
p.A373V	DO38495	STAD	ICGC	PTSTS	DEG_SPOP_SBC_1	0.1944
p.R373L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	0.1944
p.R373L	ACH-000951	Lung Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.1944
p.R373L	NCI-H2342	lung	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.1944
p.E390K	MCC13	skin	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.1111
p.E388K	MCC13	skin	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.1667
p.E369K	SUIT-2	pancreas	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.0833
p.N376K	T98G	central_nervous_system	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.2778
p.V389M	MKN28	stomach	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.1389
p.E370K	SUIT-2	pancreas	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.2222
p.P389T	H513	pleura	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.1389
p.E391K	MCC13	skin	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.0833
p.V387M	MKN28	stomach	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.1944
p.R377C	NMC-G1	central_nervous_system	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.3056
p.V390M	MKN28	stomach	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1764:1768	PTSTS	SPOP	0.7279	More...
Q12809	Potassium voltage-gated channel subfamily H member 2	DEG_SPOP_SBC_1	1088:1092	PTSTS	SPOP	0.9344	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	181:185	PTSTS	SPOP	0.9991	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	712:716	PTSTS	SPOP	0.9904	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	888:892	PTSTS	SPOP	0.9366	More...
Q6ZMT4	Lysine-specific demethylase 7A	DEG_SPOP_SBC_1	725:729	PTSTS	SPOP	0.964	More...
Q70CQ2	Ubiquitin carboxyl-terminal hydrolase 34	DEG_SPOP_SBC_1	3382:3386	PTSTS	SPOP	0.9803	More...
Q8N5H7	SH2 domain-containing protein 3C	DEG_SPOP_SBC_1	378:382	PTSTS	SPOP	0.9446	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	1838:1842	PTSTS	SPOP	0.8657	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	516:520	PTSTS	SPOP	0.9952	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	200:204	PTSTS	SPOP	0.9952	More...
Q9Y580	RNA-binding protein 7	DEG_SPOP_SBC_1	109:113	PTSTS	SPOP	0.9723	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	113:117	PTSTS	SPOP	0.996	More...
A8MVS5	Protein HIDE1	DEG_SPOP_SBC_1	211:215	PTSTS	SPOP	0.9885	More...
Q9UHA2	SS18-like protein 2	DEG_SPOP_SBC_1	69:73	PTSTS	SPOP	0.905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSTS

Degron related mutations and impact score

Drug responses associated with SH2D3C mutations

All proteins holding degron of PTSTS