DegronMD - Q70CQ2(USP34)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N2187K	TCGA-AC-A3YJ	BRCA	TCGA	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation altering degron motif	0.5806
p.N2187K	DO44208	BRCA	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation altering degron motif	0.5806
p.P2175L	TCGA-B5-A3FC	UCEC	TCGA	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.1389
p.P2175L	DO41871	UCEC	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.1389
p.S577R	TCGA-EE-A2MU	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2778
p.S577R	DO37436	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2778
p.L2185I	TCGA-EO-A3AY	UCEC	TCGA	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation altering degron motif	0.6063
p.L2185I	DO8898	COAD	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation altering degron motif	0.6063
p.L2185I	DO43202	UCEC	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation altering degron motif	0.6063
p.Y2184C	TCGA-LN-A4MQ	ESCA	TCGA	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation altering degron motif	0.5976
p.S576C	TCGA-NC-A5HD	LUSC	TCGA	PGSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.25
p.S576C	DO219184	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.25
p.Q2198K	TCGA-X7-A8M0	THYM	TCGA	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.0556
p.K2179E	DO222404	BTCA	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation substituting flanking lysine	0.3611
p.H585N	DO228948	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2778
p.D3387E	DO228976	LICA	ICGC	VLTPTST	DEG_SCF_FBW7_1	3379:3385	Mutation rewiring degron network	0.2778
p.D3387E	DO228976	LICA	ICGC	PTSTS	DEG_SPOP_SBC_1	3382:3386	Mutation rewiring degron network	0.3056
p.N2181I	DO231628	LINC	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.3056
p.G575V	SIDM00781	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2222
p.G575V	ACH-001199	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2222
p.G575V	SNU-C2B	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2222
p.V2191L	SIDM01093	Cervical Carcinoma	GDSC	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.25
p.V2191L	ACH-000556	Cervical Cancer	CCLE	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.25
p.V2191L	SiHa	cervix	COSMIC	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.25
p.I2172M	SIDM00537	Colorectal Carcinoma	GDSC	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.0556
p.I2172M	ACH-000982	Colon/Colorectal Cancer	CCLE	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.0556
p.I2172M	ACH-001345	Colon/Colorectal Cancer	CCLE	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.0556
p.I2172M	GP5d	large intestine	COSMIC	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.0556
p.T3383M	SIDM01721	Non-Cancerous	GDSC	VLTPTST	DEG_SCF_FBW7_1	3379:3385	Mutation altering degron motif	0.6312
p.T3383M	SIDM01721	Non-Cancerous	GDSC	PTSTS	DEG_SPOP_SBC_1	3382:3386	Mutation altering degron motif	0.6312
p.D574H	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1944
p.D574H	ACH-000851	Lung Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1944
p.A2189S	ACH-002460	Skin Cancer	CCLE	KWYLFND	LIG_APCC_ABBAyCdc20_2	2182:2188	Mutation rewiring degron network	0.3056

Kaplan plot for USP34 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP34

UniProt ID: Q70CQ2

Entrez ID: 9736

Protein name: Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP34 in