DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VLTPTST
Uniprot ID:
Q70CQ2
Source protein:
Ubiquitin carboxyl-terminal hydrolase 34
Source gene:
USP34
Class:
DEG_SCF_FBW7_1
Location:
3379:3385
E3 ligase:
FBXW7
DEGRON score:
0.9908
ASA_SCORE:
94.0429
COIL:
0.9329
CONS_SCORE:
0.2645
DSS_SCORE:
0.6897
HELIX:
0.0303
FCONS_SCORE:
1.0017
RIG_SCORE:
0.683
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D3387E
DO228976
LICA
ICGC
VLTPTST
DEG_SCF_FBW7_1
0.2778
p.T3383M
SIDM01721
Non-Cancerous
GDSC
VLTPTST
DEG_SCF_FBW7_1
0.6312
Drug responses associated with USP34 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VLTPTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q70CQ2
Ubiquitin carboxyl-terminal hydrolase 34
DEG_SCF_FBW7_1
3379:3385
VLTPTST
FBXW7
0.9908
More...