DegronMD

Uniprot ID: Q70CQ2

Source protein: Ubiquitin carboxyl-terminal hydrolase 34

Source gene: USP34

Class: LIG_APCC_ABBAyCdc20_2

Location: 2182:2188

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.628

ASA_SCORE: 45.4

COIL: 0.2794

CONS_SCORE: 0.7304

DSS_SCORE: 0.1403

HELIX: 0.0229

FCONS_SCORE: 1.4649

RIG_SCORE: 0.9138

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N2187K	TCGA-AC-A3YJ	BRCA	TCGA	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.5806
p.N2187K	DO44208	BRCA	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.5806
p.P2175L	TCGA-B5-A3FC	UCEC	TCGA	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.1389
p.P2175L	DO41871	UCEC	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.1389
p.L2185I	TCGA-EO-A3AY	UCEC	TCGA	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.6063
p.L2185I	DO8898	COAD	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.6063
p.L2185I	DO43202	UCEC	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.6063
p.Y2184C	TCGA-LN-A4MQ	ESCA	TCGA	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.5976
p.Q2198K	TCGA-X7-A8M0	THYM	TCGA	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.0556
p.K2179E	DO222404	BTCA	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.3611
p.N2181I	DO231628	LINC	ICGC	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.3056
p.V2191L	SIDM01093	Cervical Carcinoma	GDSC	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.25
p.V2191L	ACH-000556	Cervical Cancer	CCLE	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.25
p.V2191L	SiHa	cervix	COSMIC	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.25
p.I2172M	SIDM00537	Colorectal Carcinoma	GDSC	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.0556
p.I2172M	ACH-000982	Colon/Colorectal Cancer	CCLE	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.0556
p.I2172M	ACH-001345	Colon/Colorectal Cancer	CCLE	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.0556
p.I2172M	GP5d	large_intestine	COSMIC	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.0556
p.A2189S	ACH-002460	Skin Cancer	CCLE	KWYLFND	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70CQ2	Ubiquitin carboxyl-terminal hydrolase 34	LIG_APCC_ABBAyCdc20_2	2182:2188	KWYLFND	APC,CDC20,FZR1	0.628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons