DegronMD - Q8N5H7(SH2D3C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y74F	TCGA-06-1801	GBM	TCGA	PPAY	ITCH	64:67	Mutation blocking phosphorylation signal	0.5833
p.Y74F	DO11986	GBM	ICGC	PPAY	ITCH	64:67	Mutation blocking phosphorylation signal	0.5833
p.Q499P	TCGA-35-4122	LUAD	TCGA	LQPPVRGSR	SCF_FBXL2	498:506	Mutation altering degron motif	0.7035
p.P65R	TCGA-51-4080	LUSC	TCGA	PPAY	ITCH	64:67	Mutation altering degron motif	0.7512
p.P65R	DO26441	LUSC	ICGC	PPAY	ITCH	64:67	Mutation altering degron motif	0.7512
p.R506Q	TCGA-55-7910	LUAD	TCGA	LQPPVRGSR	SCF_FBXL2	498:506	Mutation altering degron motif	0.7329
p.R503S	TCGA-85-8352	LUSC	TCGA	LQPPVRGSR	SCF_FBXL2	498:506	Mutation altering degron motif	0.7427
p.Y67H	TCGA-85-A512	LUSC	TCGA	PPAY	ITCH	64:67	Mutation altering degron motif	0.7229
p.Y67H	DO45425	LUSC	ICGC	PPAY	ITCH	64:67	Mutation altering degron motif	0.7229
p.D375Y	TCGA-86-6851	LUAD	TCGA	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.25
p.D491Y	TCGA-A5-A0G2	UCEC	TCGA	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.1389
p.E122D	TCGA-A5-A0G2	UCEC	TCGA	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.0833
p.E122D	DO41235	UCEC	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.0833
p.R373C	TCGA-AP-A1DK	UCEC	TCGA	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1944
p.R373C	SIDM00537	Colorectal Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1944
p.R373C	ACH-000982	Colon/Colorectal Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1944
p.R373C	ACH-001345	Colon/Colorectal Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1944
p.R373C	GP5d	large intestine	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1944
p.A510V	TCGA-CF-A5U8	BLCA	TCGA	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.2222
p.A510V	TCGA-HZ-7922	PAAD	TCGA	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.2222
p.A510V	SIDM00534	Colorectal Carcinoma	GDSC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.2222
p.A510V	ACH-000986	Colon/Colorectal Cancer	CCLE	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.2222
p.E512K	TCGA-EE-A2MJ	SKCM	TCGA	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.1667
p.P135T	TCGA-EE-A3AH	SKCM	TCGA	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.7031
p.P135T	DO37443	SKCM	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.7031
p.P141L	TCGA-FI-A2D0	UCEC	TCGA	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.25
p.P141L	DO43891	UCEC	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.25
p.T59M	TCGA-HJ-7597	STAD	TCGA	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1944
p.T59M	DO38195	STAD	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1944
p.V502M	TCGA-WS-AB45	COAD	TCGA	LQPPVRGSR	SCF_FBXL2	498:506	Mutation altering degron motif	0.6097
p.V502M	SIDM01169	Ovarian Carcinoma	GDSC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation altering degron motif	0.6097
p.V502M	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation altering degron motif	0.6097
p.V502M	NCI-H1651	lung	COSMIC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation altering degron motif	0.6097
p.V502M	TOV-21G	ovary	COSMIC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation altering degron motif	0.6097
p.R66H	DO219003	BLCA	ICGC	PPAY	ITCH	64:67	Mutation altering degron motif	0.8244
p.R66H	DO10582	COAD	ICGC	PPAY	ITCH	64:67	Mutation altering degron motif	0.8244
p.R138C	DO50547	BOCA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.8301
p.R138C	DO9698	COAD	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.8301
p.P134S	DO222574	BTCA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.6752
p.S62F	DO219723	CESC	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.2778
p.E58K	DO8127	COAD	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1667
p.E58K	DO231981	LICA	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1667
p.E58K	C32	skin	COSMIC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1667
p.T72A	DO49095	COAD	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1944
p.Q61P	DO230326	COCA	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.25
p.Q56K	DO230326	COCA	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1111
p.A143V	DO233018	GACA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.1944
p.A143V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.1944
p.I67T	DO233171	GACA	ICGC	PPAY	ITCH	64:67	Mutation altering degron motif	0.7078
p.R144C	DO233203	GACA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.1667
p.E514K	DO233913	GACA	ICGC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.1111
p.L375I	DO11878	GBM	ICGC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.25
p.A135T	DO44440	HNSC	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.7139
p.A135T	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.7139
p.L144I	DO228974	LICA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.1667
p.A76E	DO228974	LICA	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.P141T	DO229018	LICA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.25
p.H132Q	DO229018	LICA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.7582
p.A136E	DO229028	LICA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.659
p.L492M	DO229036	LICA	ICGC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation blocking phosphorylation signal	0.6111
p.L57I	DO229008	LICA	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1389
p.L57I	ChaGo-K-1	lung	COSMIC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1389
p.R69H	DO45155	LIRI	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.2778
p.Q145P	DO23782	LUAD	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.1389
p.L124M	DO25937	LUAD	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.1389
p.G379D	DO26444	LUSC	ICGC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation altering degron motif	0.7198
p.G379D	DO41572	UCEC	ICGC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation altering degron motif	0.7198
p.S125F	DO45482	LUSC	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.1667
p.P374H	DO45431	LUSC	ICGC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2222
p.G376R	DO220877	MELA	ICGC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.P385S	DO222363	MELA	ICGC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.25
p.S54R	DO222595	MELA	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.0556
p.P385L	DO222683	MELA	ICGC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.25
p.P385L	DO37417	SKCM	ICGC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.25
p.L497M	DO46657	PAAD	ICGC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.3056
p.G372E	DO37406	SKCM	ICGC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1667
p.P370S	DO37432	SKCM	ICGC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation substituting flanking lysine	0.2222
p.P55S	DO47601	SKCM	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.E58D	DO47569	SKCM	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1667
p.H140Y	DO51259	SKCM	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.2778
p.P128S	DO51298	SKCM	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.25
p.A373V	DO38495	STAD	ICGC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1944
p.D147Y	DO229259	THCA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.0833
p.S59I	DO229208	THCA	ICGC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1944
p.L504P	DO229245	THCA	ICGC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation altering degron motif	0.7582
p.Q122H	DO41235	UCEC	ICGC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.0833
p.G129D	SIDM02021	Esophageal Carcinoma	GDSC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.2778
p.R503H	SIDM00215	Colorectal Carcinoma	GDSC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation altering degron motif	0.8244
p.R503H	SNU-283	large intestine	COSMIC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation altering degron motif	0.8244
p.P490S	SIDM00200	Ewing's Sarcoma	GDSC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.1111
p.P490S	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.1111
p.R75W	SIDM00529	Breast Carcinoma	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1111
p.R75W	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1111
p.R75W	SIDM00931	Thyroid Gland Carcinoma	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1111
p.R75W	SIDM01133	Other Solid Cancers	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1111
p.R75W	SIDM00808	Burkitt's Lymphoma	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1111
p.G62E	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.2778
p.G62E	SIDM00140	Melanoma	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.2778
p.G62E	COLO-792	skin	COSMIC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.2778
p.G62E	NCI-H1915	lung	COSMIC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.2778
p.R60W	SIDM01716	Non-Cancerous	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.2222
p.R60W	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.2222
p.R60W	SIDM00175	Melanoma	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.2222
p.R60W	SIDM00807	Bladder Carcinoma	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.2222
p.S75I	SIDM00282	Colorectal Carcinoma	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1111
p.S75I	ACH-000998	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1111
p.S75I	CW-2	large intestine	COSMIC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1111
p.R373L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1944
p.R373L	ACH-000951	Lung Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1944
p.R373L	NCI-H2342	lung	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1944
p.P58S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1667
p.P58S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1667
p.E390K	MCC13	skin	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1111
p.V148M	NCI-H1651	lung	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.0556
p.V148M	TOV-21G	ovary	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.0556
p.E388K	MCC13	skin	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1667
p.P496H	LS-411N	large intestine	COSMIC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.2778
p.L489P	KCL-22	haematopoietic and lymphoid tissue	COSMIC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.0833
p.L490P	KCL-22	haematopoietic and lymphoid tissue	COSMIC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.1111
p.L147I	ChaGo-K-1	lung	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.0833
p.L58I	ChaGo-K-1	lung	COSMIC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1667
p.E369K	SUIT-2	pancreas	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.0833
p.R138H	TMK-1	stomach	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.8244
p.S132T	KYSE-270	oesophagus	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.7116
p.R508C	SK-UT-1	soft tissue	COSMIC	LQPPVRGSR	SCF_FBXL2	498:506	Mutation rewiring degron network	0.2778
p.N376K	T98G	central nervous system	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.2778
p.V389M	MKN28	stomach	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1389
p.R141H	TMK-1	stomach	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.25
p.A137T	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.7139
p.R140H	TMK-1	stomach	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation rewiring degron network	0.2778
p.L55I	ChaGo-K-1	lung	COSMIC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.0833
p.E370K	SUIT-2	pancreas	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation substituting flanking lysine	0.2222
p.P389T	H513	pleura	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1389
p.E391K	MCC13	skin	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.0833
p.A138T	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	131:138	Mutation altering degron motif	0.7139
p.V387M	MKN28	stomach	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1944
p.A73V	REH	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	64:67	Mutation rewiring degron network	0.1667
p.R377C	NMC-G1	central nervous system	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.3056
p.V390M	MKN28	stomach	COSMIC	PTSTS	DEG_SPOP_SBC_1	378:382	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH2D3C

UniProt ID: Q8N5H7

Entrez ID: 10044

Protein name: SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH2D3C in