DegronMD

Uniprot ID: Q8N5H7

Source protein: SH2 domain-containing protein 3C

Source gene: SH2D3C

Class: DEG_SCF_FBW7_2

Location: 131:138

E3 ligase: FBXW7

DEGRON score: 0.8447

ASA_SCORE: 87.8875

COIL: 0.88

CONS_SCORE: 0.3034

DSS_SCORE: 0.6895

HELIX: 0.0828

FCONS_SCORE: 1.0642

RIG_SCORE: 0.6575

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E122D	TCGA-A5-A0G2	UCEC	TCGA	LEDTPAME	DEG_SCF_FBW7_2	0.0833
p.E122D	DO41235	UCEC	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.0833
p.P135T	TCGA-EE-A3AH	SKCM	TCGA	LEDTPAME	DEG_SCF_FBW7_2	0.7031
p.P135T	DO37443	SKCM	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.7031
p.P141L	TCGA-FI-A2D0	UCEC	TCGA	LEDTPAME	DEG_SCF_FBW7_2	0.25
p.P141L	DO43891	UCEC	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.25
p.R138C	DO50547	BOCA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.8301
p.R138C	DO9698	COAD	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.8301
p.P134S	DO222574	BTCA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.6752
p.A143V	DO233018	GACA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.1944
p.A143V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LEDTPAME	DEG_SCF_FBW7_2	0.1944
p.R144C	DO233203	GACA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.1667
p.A135T	DO44440	HNSC	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.7139
p.A135T	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	0.7139
p.L144I	DO228974	LICA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.1667
p.P141T	DO229018	LICA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.25
p.H132Q	DO229018	LICA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.7582
p.A136E	DO229028	LICA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.659
p.Q145P	DO23782	LUAD	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.1389
p.L124M	DO25937	LUAD	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.1389
p.S125F	DO45482	LUSC	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.1667
p.H140Y	DO51259	SKCM	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.2778
p.P128S	DO51298	SKCM	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.25
p.D147Y	DO229259	THCA	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.0833
p.Q122H	DO41235	UCEC	ICGC	LEDTPAME	DEG_SCF_FBW7_2	0.0833
p.G129D	SIDM02021	Esophageal Carcinoma	GDSC	LEDTPAME	DEG_SCF_FBW7_2	0.2778
p.V148M	NCI-H1651	lung	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	0.0556
p.V148M	TOV-21G	ovary	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	0.0556
p.L147I	ChaGo-K-1	lung	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	0.0833
p.R138H	TMK-1	stomach	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	0.8244
p.S132T	KYSE-270	oesophagus	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	0.7116
p.R141H	TMK-1	stomach	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	0.25
p.A137T	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	0.7139
p.R140H	TMK-1	stomach	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	0.2778
p.A138T	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LEDTPAME	DEG_SCF_FBW7_2	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LEDTPAME

Degron related mutations and impact score

Drug responses associated with SH2D3C mutations

All proteins holding degron of LEDTPAME

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5H7	SH2 domain-containing protein 3C	DEG_SCF_FBW7_2	131:138	LEDTPAME	FBXW7	0.8447	More...