DegronMD

Uniprot ID: Q8N5H7

Source protein: SH2 domain-containing protein 3C

Source gene: SH2D3C

Class: SCF_FBXL2

Location: 498:506

E3 ligase: FBXL2

DEGRON score: 0.999

ASA_SCORE: 77.8778

COIL: 0.8139

CONS_SCORE: 0.4165

DSS_SCORE: 0.5649

HELIX: 0.1257

FCONS_SCORE: 1.1766

RIG_SCORE: 0.6695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q499P	TCGA-35-4122	LUAD	TCGA	LQPPVRGSR	SCF_FBXL2	0.7035
p.R506Q	TCGA-55-7910	LUAD	TCGA	LQPPVRGSR	SCF_FBXL2	0.7329
p.R503S	TCGA-85-8352	LUSC	TCGA	LQPPVRGSR	SCF_FBXL2	0.7427
p.D491Y	TCGA-A5-A0G2	UCEC	TCGA	LQPPVRGSR	SCF_FBXL2	0.1389
p.A510V	TCGA-CF-A5U8	BLCA	TCGA	LQPPVRGSR	SCF_FBXL2	0.2222
p.A510V	TCGA-HZ-7922	PAAD	TCGA	LQPPVRGSR	SCF_FBXL2	0.2222
p.A510V	SIDM00534	Colorectal Carcinoma	GDSC	LQPPVRGSR	SCF_FBXL2	0.2222
p.A510V	ACH-000986	Colon/Colorectal Cancer	CCLE	LQPPVRGSR	SCF_FBXL2	0.2222
p.E512K	TCGA-EE-A2MJ	SKCM	TCGA	LQPPVRGSR	SCF_FBXL2	0.1667
p.V502M	TCGA-WS-AB45	COAD	TCGA	LQPPVRGSR	SCF_FBXL2	0.6097
p.V502M	SIDM01169	Ovarian Carcinoma	GDSC	LQPPVRGSR	SCF_FBXL2	0.6097
p.V502M	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	LQPPVRGSR	SCF_FBXL2	0.6097
p.V502M	NCI-H1651	lung	COSMIC	LQPPVRGSR	SCF_FBXL2	0.6097
p.V502M	TOV-21G	ovary	COSMIC	LQPPVRGSR	SCF_FBXL2	0.6097
p.E514K	DO233913	GACA	ICGC	LQPPVRGSR	SCF_FBXL2	0.1111
p.L492M	DO229036	LICA	ICGC	LQPPVRGSR	SCF_FBXL2	0.6111
p.L497M	DO46657	PAAD	ICGC	LQPPVRGSR	SCF_FBXL2	0.3056
p.L504P	DO229245	THCA	ICGC	LQPPVRGSR	SCF_FBXL2	0.7582
p.R503H	SIDM00215	Colorectal Carcinoma	GDSC	LQPPVRGSR	SCF_FBXL2	0.8244
p.R503H	SNU-283	large_intestine	COSMIC	LQPPVRGSR	SCF_FBXL2	0.8244
p.P490S	SIDM00200	Ewing's Sarcoma	GDSC	LQPPVRGSR	SCF_FBXL2	0.1111
p.P490S	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQPPVRGSR	SCF_FBXL2	0.1111
p.P496H	LS-411N	large_intestine	COSMIC	LQPPVRGSR	SCF_FBXL2	0.2778
p.L489P	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LQPPVRGSR	SCF_FBXL2	0.0833
p.L490P	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LQPPVRGSR	SCF_FBXL2	0.1111
p.R508C	SK-UT-1	soft_tissue	COSMIC	LQPPVRGSR	SCF_FBXL2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5H7	SH2 domain-containing protein 3C	SCF_FBXL2	498:506	LQPPVRGSR	FBXL2	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQPPVRGSR

Degron related mutations and impact score

Drug responses associated with SH2D3C mutations

All proteins holding degron of LQPPVRGSR