DegronMD

Uniprot ID: Q659C4

Source protein: La-related protein 1B

Source gene: LARP1B

Class: DEG_SPOP_SBC_1

Location: 888:892

E3 ligase: SPOP

DEGRON score: 0.9366

ASA_SCORE: 84.9

COIL: 0.851

CONS_SCORE: 0.286

DSS_SCORE: 0.7854

HELIX: 0.1264

FCONS_SCORE: 1.0471

RIG_SCORE: 0.5994

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I898L	TCGA-IQ-A61G	HNSC	TCGA	PTSTS	DEG_SPOP_SBC_1	0.1667
p.S890F	TCGA-XV-A9W5	SKCM	TCGA	PTSTS	DEG_SPOP_SBC_1	0.7982
p.T891S	SIDM00761	Small Cell Lung Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	0.6005
p.T891S	ACH-000752	Lung Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.6005
p.T891S	NCI-H196	lung	COSMIC	PTSTS	DEG_SPOP_SBC_1	0.6005
p.S892N	ACH-000872	Lung Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.7069
p.Q895R	ACH-001063	Ovarian Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1764:1768	PTSTS	SPOP	0.7279	More...
Q12809	Potassium voltage-gated channel subfamily H member 2	DEG_SPOP_SBC_1	1088:1092	PTSTS	SPOP	0.9344	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	181:185	PTSTS	SPOP	0.9991	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	712:716	PTSTS	SPOP	0.9904	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	888:892	PTSTS	SPOP	0.9366	More...
Q6ZMT4	Lysine-specific demethylase 7A	DEG_SPOP_SBC_1	725:729	PTSTS	SPOP	0.964	More...
Q70CQ2	Ubiquitin carboxyl-terminal hydrolase 34	DEG_SPOP_SBC_1	3382:3386	PTSTS	SPOP	0.9803	More...
Q8N5H7	SH2 domain-containing protein 3C	DEG_SPOP_SBC_1	378:382	PTSTS	SPOP	0.9446	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	1838:1842	PTSTS	SPOP	0.8657	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	516:520	PTSTS	SPOP	0.9952	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	200:204	PTSTS	SPOP	0.9952	More...
Q9Y580	RNA-binding protein 7	DEG_SPOP_SBC_1	109:113	PTSTS	SPOP	0.9723	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	113:117	PTSTS	SPOP	0.996	More...
A8MVS5	Protein HIDE1	DEG_SPOP_SBC_1	211:215	PTSTS	SPOP	0.9885	More...
Q9UHA2	SS18-like protein 2	DEG_SPOP_SBC_1	69:73	PTSTS	SPOP	0.905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons