DegronMD - Q92908(GATA6)

GO - Biological processes (BP): animal organ formation [GO:0048645]; atrioventricular canal development [GO:0036302]; atrioventricular node development [GO:0003162]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cell fate commitment [GO:0045165]; cellular response to BMP stimulus [GO:0071773]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to hypoxia [GO:0071456]; club cell differentiation [GO:0060486]; endodermal cell fate determination [GO:0007493]; epithelial cell differentiation [GO:0030855]; G1 to G0 transition involved in cell differentiation [GO:0070315]; gene expression [GO:0010467]; heart contraction [GO:0060047]; intestinal epithelial cell differentiation [GO:0060575]; in utero embryonic development [GO:0001701]; liver development [GO:0001889]; lung saccule development [GO:0060430]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of sebum secreting cell proliferation [GO:1904003]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta1 production [GO:0032911]; negative regulation of transforming growth factor beta2 production [GO:0032912]; odontogenesis of dentin-containing tooth [GO:0042475]; outflow tract septum morphogenesis [GO:0003148]; pancreatic A cell differentiation [GO:0003310]; phospholipid metabolic process [GO:0006644]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta activation [GO:1901390]; regulation of antimicrobial humoral response [GO:0002759]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to growth factor [GO:0070848]; response to retinoic acid [GO:0032526]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; sebaceous gland cell differentiation [GO:0001949]; sinoatrial node development [GO:0003163]; skin epidermis development [GO:0098773]; smooth muscle cell differentiation [GO:0051145]; tube morphogenesis [GO:0035239]; type B pancreatic cell differentiation [GO:0003309]; type II pneumocyte differentiation [GO:0060510] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N529K	TCGA-12-0688	GBM	TCGA	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation rewiring degron network	0.0556
p.N529K	TCGA-12-0688	GBM	TCGA	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation rewiring degron network	0.0833
p.N529K	DO11088	GBM	ICGC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation rewiring degron network	0.0556
p.N529K	DO11088	GBM	ICGC	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation rewiring degron network	0.0833
p.N529K	SIDM00193	Colorectal Carcinoma	GDSC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation rewiring degron network	0.0556
p.N529K	SIDM00193	Colorectal Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation rewiring degron network	0.0833
p.N529K	ACH-000991	Colon/Colorectal Cancer	CCLE	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation rewiring degron network	0.0556
p.N529K	ACH-000991	Colon/Colorectal Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation rewiring degron network	0.0833
p.N529K	SNU-81	large intestine	COSMIC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation rewiring degron network	0.0556
p.N529K	SNU-81	large intestine	COSMIC	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation rewiring degron network	0.0833
p.N529H	TCGA-64-1679	LUAD	TCGA	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation rewiring degron network	0.0556
p.N529H	TCGA-64-1679	LUAD	TCGA	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation rewiring degron network	0.0833
p.N529H	DO26200	LUAD	ICGC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation rewiring degron network	0.0556
p.N529H	DO26200	LUAD	ICGC	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation rewiring degron network	0.0833
p.P516L	TCGA-64-5781	LUAD	TCGA	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation altering degron motif	0.7582
p.P516L	TCGA-64-5781	LUAD	TCGA	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation altering degron motif	0.7582
p.P516L	DO23740	LUAD	ICGC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation altering degron motif	0.7582
p.P516L	DO23740	LUAD	ICGC	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation altering degron motif	0.7582
p.T503S	TCGA-BR-6452	STAD	TCGA	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation rewiring degron network	0.0833
p.T503S	DO38404	STAD	ICGC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation rewiring degron network	0.0833
p.P38T	TCGA-EE-A17Y	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.7031
p.P38T	DO47459	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.7031
p.P38H	TCGA-ER-A196	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.7694
p.P38H	DO47474	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.7694
p.S520C	TCGA-FD-A3SS	BLCA	TCGA	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation altering degron motif	0.7541
p.S520C	DO737	BLCA	ICGC	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation altering degron motif	0.7541
p.P36L	TCGA-FW-A3R5	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2778
p.P36L	DO37406	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2778
p.I512T	DO48404	BLCA	ICGC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation altering degron motif	0.7078
p.D525N	DO222838	BTCA	ICGC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation rewiring degron network	0.1667
p.D525N	DO222838	BTCA	ICGC	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation rewiring degron network	0.1944
p.M514I	DO222838	BTCA	ICGC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation altering degron motif	0.6507
p.T517A	DO233766	GACA	ICGC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation altering degron motif	0.6028
p.T517A	DO233766	GACA	ICGC	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation altering degron motif	0.6028
p.C504F	DO229027	LICA	ICGC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation rewiring degron network	0.1111
p.S45C	DO32908	PACA	ICGC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.25
p.G50R	SIDM01036	Plasma Cell Myeloma	GDSC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1111
p.G50R	ACH-000653	Myeloma	CCLE	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1111
p.G50R	JJN-3	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1111
p.G49C	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1389
p.G49C	ACH-001680	Lymphoma	CCLE	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1389
p.G49C	U-698-M	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1389
p.R52W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0556
p.R52W	ACH-002256	Leukemia	CCLE	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0556
p.R52W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0556
p.E51K	SIDM00687	Gastric Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0833
p.E51K	SIDM00574	Glioblastoma	GDSC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0833
p.E51K	no-10	central nervous system	COSMIC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0833
p.E51K	KATOIII	stomach	COSMIC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0833
p.K502M	SIDM01118	Small Cell Lung Carcinoma	GDSC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation substituting flanking lysine	0.1667
p.K502M	ACH-002175	Lung Cancer	CCLE	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation substituting flanking lysine	0.1667
p.K502M	NCI-H740	lung	COSMIC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation substituting flanking lysine	0.1667
p.S44F	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2778
p.S44F	ACH-000264	Lung Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2778
p.S44F	Calu-6	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2778
p.P513H	SIDM01739	Small Cell Lung Carcinoma	GDSC	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation altering degron motif	0.6583
p.P513H	ACH-000297	Lung Cancer	CCLE	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation altering degron motif	0.6583
p.T517I	ACH-001389	Breast Cancer	CCLE	IPMTPTST	DEG_SCF_FBW7_1	512:519	Mutation altering degron motif	0.5966
p.T517I	ACH-001389	Breast Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	516:520	Mutation altering degron motif	0.5966

Kaplan plot for GATA6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GATA6

UniProt ID: Q92908

Entrez ID: 2627

Protein name: Transcription factor GATA-6 (GATA-binding factor 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GATA6 in