DegronMD

Uniprot ID: Q92908

Source protein: Transcription factor GATA-6

Source gene: GATA6

Class: DEG_SPOP_SBC_1

Location: 38:42

E3 ligase: SPOP

DEGRON score: 0.7589

ASA_SCORE: 87.62

COIL: 0.9338

CONS_SCORE: 0.3234

DSS_SCORE: 0.7135

HELIX: 0.04

FCONS_SCORE: 0.9536

RIG_SCORE: 0.5145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P38T	TCGA-EE-A17Y	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	0.7031
p.P38T	DO47459	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	0.7031
p.P38H	TCGA-ER-A196	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	0.7694
p.P38H	DO47474	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	0.7694
p.P36L	TCGA-FW-A3R5	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	0.2778
p.P36L	DO37406	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	0.2778
p.S45C	DO32908	PACA	ICGC	PISSS	DEG_SPOP_SBC_1	0.25
p.G50R	SIDM01036	Plasma Cell Myeloma	GDSC	PISSS	DEG_SPOP_SBC_1	0.1111
p.G50R	ACH-000653	Myeloma	CCLE	PISSS	DEG_SPOP_SBC_1	0.1111
p.G50R	JJN-3	haematopoietic_and_lymphoid_tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1111
p.G49C	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.1389
p.G49C	ACH-001680	Lymphoma	CCLE	PISSS	DEG_SPOP_SBC_1	0.1389
p.G49C	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1389
p.R52W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PISSS	DEG_SPOP_SBC_1	0.0556
p.R52W	ACH-002256	Leukemia	CCLE	PISSS	DEG_SPOP_SBC_1	0.0556
p.R52W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	0.0556
p.E51K	SIDM00687	Gastric Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.0833
p.E51K	SIDM00574	Glioblastoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.0833
p.E51K	no-10	central_nervous_system	COSMIC	PISSS	DEG_SPOP_SBC_1	0.0833
p.E51K	KATOIII	stomach	COSMIC	PISSS	DEG_SPOP_SBC_1	0.0833
p.S44F	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.2778
p.S44F	ACH-000264	Lung Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	0.2778
p.S44F	Calu-6	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15444	C-C motif chemokine 25	DEG_SPOP_SBC_1	132:136	PISSS	SPOP	0.8813	More...
O75030	Microphthalmia-associated transcription factor	DEG_SPOP_SBC_1	47:51	PISSS	SPOP	0.9949	More...
O94864	STAGA complex 65 subunit gamma	DEG_SPOP_SBC_1	11:15	PISSS	SPOP	0.9981	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	314:318	PISSS	SPOP	0.9982	More...
P26367	Paired box protein Pax-6	DEG_SPOP_SBC_1	286:290	PISSS	SPOP	0.8502	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	586:590	PISSS	SPOP	0.963	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	931:935	PISSS	SPOP	0.9118	More...
Q8IZH2	5'-3' exoribonuclease 1	DEG_SPOP_SBC_1	1684:1688	PISSS	SPOP	0.9961	More...
Q8N983	39S ribosomal protein L43, mitochondrial	DEG_SPOP_SBC_1	184:188	PISSS	SPOP	0.8798	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	38:42	PISSS	SPOP	0.7589	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	532:536	PISSS	SPOP	0.9978	More...
Q7M4L6	SH2 domain-containing adapter protein F	DEG_SPOP_SBC_1	62:66	PISSS	SPOP	0.9333	More...
A6NIR3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5	DEG_SPOP_SBC_1	354:358	PISSS	SPOP	0.9883	More...
Q5VTM2	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9	DEG_SPOP_SBC_1	399:403	PISSS	SPOP	0.9606	More...
Q5VUJ5	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9817	More...
Q5VW22	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9118	More...
Q8TF27	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11	DEG_SPOP_SBC_1	193:197	PISSS	SPOP	0.9254	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1507:1511	PISSS	SPOP	0.9387	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISSS

Degron related mutations and impact score

Drug responses associated with GATA6 mutations

All proteins holding degron of PISSS