DegronMD

Uniprot ID: P38398

Source protein: Breast cancer type 1 susceptibility protein

Source gene: BRCA1

Class: DEG_SPOP_SBC_1

Location: 586:590

E3 ligase: SPOP

DEGRON score: 0.963

ASA_SCORE: 79.82

COIL: 0.8144

CONS_SCORE: 0.3975

DSS_SCORE: 0.4401

HELIX: 0.133

FCONS_SCORE: 1.0079

RIG_SCORE: 0.6646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E597K	TCGA-B5-A1MR	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	0.1389
p.V577M	DO51926	BLCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.0833
p.D597V	DO218669	BRCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.1389
p.Q579R	DO225328	BRCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.1389
p.T590N	DO51628	CESC	ICGC	PISSS	DEG_SPOP_SBC_1	0.7055
p.S580F	DO44305	CESC	ICGC	PISSS	DEG_SPOP_SBC_1	0.1667
p.D591N	DO222452	ESCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.3056
p.R595T	DO44431	HNSC	ICGC	PISSS	DEG_SPOP_SBC_1	0.1944
p.S599G	DO51701	PAAD	ICGC	PISSS	DEG_SPOP_SBC_1	0.0833
p.C597W	DO41458	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	0.1389
p.R595Q	DMS-273	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1944
p.C593F	NCI-H2347	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15444	C-C motif chemokine 25	DEG_SPOP_SBC_1	132:136	PISSS	SPOP	0.8813	More...
O75030	Microphthalmia-associated transcription factor	DEG_SPOP_SBC_1	47:51	PISSS	SPOP	0.9949	More...
O94864	STAGA complex 65 subunit gamma	DEG_SPOP_SBC_1	11:15	PISSS	SPOP	0.9981	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	314:318	PISSS	SPOP	0.9982	More...
P26367	Paired box protein Pax-6	DEG_SPOP_SBC_1	286:290	PISSS	SPOP	0.8502	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	586:590	PISSS	SPOP	0.963	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	931:935	PISSS	SPOP	0.9118	More...
Q8IZH2	5'-3' exoribonuclease 1	DEG_SPOP_SBC_1	1684:1688	PISSS	SPOP	0.9961	More...
Q8N983	39S ribosomal protein L43, mitochondrial	DEG_SPOP_SBC_1	184:188	PISSS	SPOP	0.8798	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	38:42	PISSS	SPOP	0.7589	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	532:536	PISSS	SPOP	0.9978	More...
Q7M4L6	SH2 domain-containing adapter protein F	DEG_SPOP_SBC_1	62:66	PISSS	SPOP	0.9333	More...
A6NIR3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5	DEG_SPOP_SBC_1	354:358	PISSS	SPOP	0.9883	More...
Q5VTM2	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9	DEG_SPOP_SBC_1	399:403	PISSS	SPOP	0.9606	More...
Q5VUJ5	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9817	More...
Q5VW22	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9118	More...
Q8TF27	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11	DEG_SPOP_SBC_1	193:197	PISSS	SPOP	0.9254	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1507:1511	PISSS	SPOP	0.9387	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISSS

Degron related mutations and impact score

Drug responses associated with BRCA1 mutations

All proteins holding degron of PISSS