DegronMD

Uniprot ID: A6NIR3

Source protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5

Source gene: AGAP5

Class: DEG_SPOP_SBC_1

Location: 354:358

E3 ligase: SPOP

DEGRON score: 0.9883

ASA_SCORE: 70.5

COIL: 0.7856

CONS_SCORE: 0.3936

DSS_SCORE: 0.3901

HELIX: 0.0812

FCONS_SCORE: 1.1862

RIG_SCORE: 0.6901

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I355L	SIDM00941	Kidney Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.6063
p.I355L	SIDM01594	Breast Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.6063
p.I355L	ACH-000083	Non-Cancerous	CCLE	PISSS	DEG_SPOP_SBC_1	0.6063
p.I355L	ACH-000433	Kidney Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	0.6063
p.N361D	DO228947	LICA	ICGC	PISSS	DEG_SPOP_SBC_1	0.25
p.N361D	DO229218	THCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.25
p.N361D	SIDM01577	Plasma Cell Myeloma	GDSC	PISSS	DEG_SPOP_SBC_1	0.25
p.N361D	SIDM01498	Acute Myeloid Leukemia	GDSC	PISSS	DEG_SPOP_SBC_1	0.25
p.N361D	SIDM01660	Kidney Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.25
p.N361D	SIDM00173	Head and Neck Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.25
p.G362S	TCGA-B5-A1MX	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	0.2222
p.G362S	DO41999	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	0.2222
p.S350L	TCGA-CQ-A4CD	HNSC	TCGA	PISSS	DEG_SPOP_SBC_1	0.2222
p.S350L	DO49038	HNSC	ICGC	PISSS	DEG_SPOP_SBC_1	0.2222

Showing 1 to 14 of 14 entries

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Drug responses associated with AGAP5 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PISSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N983	39S ribosomal protein L43, mitochondrial	DEG_SPOP_SBC_1	184:188	PISSS	SPOP	0.8798	More...
Q8IZH2	5'-3' exoribonuclease 1	DEG_SPOP_SBC_1	1684:1688	PISSS	SPOP	0.9961	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1507:1511	PISSS	SPOP	0.9387	More...
Q8TF27	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11	DEG_SPOP_SBC_1	193:197	PISSS	SPOP	0.9254	More...
A6NIR3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5	DEG_SPOP_SBC_1	354:358	PISSS	SPOP	0.9883	More...
Q5VW22	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9118	More...
Q5VTM2	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9	DEG_SPOP_SBC_1	399:403	PISSS	SPOP	0.9606	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	586:590	PISSS	SPOP	0.963	More...
O15444	C-C motif chemokine 25	DEG_SPOP_SBC_1	132:136	PISSS	SPOP	0.8813	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	314:318	PISSS	SPOP	0.9982	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	931:935	PISSS	SPOP	0.9118	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	532:536	PISSS	SPOP	0.9978	More...
O75030	Microphthalmia-associated transcription factor	DEG_SPOP_SBC_1	47:51	PISSS	SPOP	0.9949	More...
P26367	Paired box protein Pax-6	DEG_SPOP_SBC_1	286:290	PISSS	SPOP	0.8502	More...
Q5VUJ5	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9817	More...
Q7M4L6	SH2 domain-containing adapter protein F	DEG_SPOP_SBC_1	62:66	PISSS	SPOP	0.9333	More...
O94864	STAGA complex 65 subunit gamma	DEG_SPOP_SBC_1	11:15	PISSS	SPOP	0.9981	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	38:42	PISSS	SPOP	0.7589	More...

Showing 1 to 18 of 18 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISSS

Degron related mutations and impact score

Drug responses associated with AGAP5 mutations

All proteins holding degron of PISSS