DegronMD - O75030(MITF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S51F	TCGA-AC-A23H	BRCA	TCGA	PISSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.9093
p.S51F	DO2401	BRCA	ICGC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.9093
p.R60H	TCGA-AX-A1CE	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0833
p.R60H	DO42280	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0833
p.S49R	TCGA-BR-6452	STAD	TCGA	PISSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.8538
p.S49R	DO38404	STAD	ICGC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.8538
p.A38T	TCGA-CM-6172	COAD	TCGA	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0833
p.A38T	DO8376	COAD	ICGC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0833
p.M53L	TCGA-DI-A1BU	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.2778
p.M53L	DO42023	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.2778
p.H18R	TCGA-EO-A22R	UCEC	TCGA	SESGIVPDF	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.H18R	DO42713	UCEC	ICGC	SESGIVPDF	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.R56C	TCGA-EY-A549	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1944
p.R56C	DO230335	COCA	ICGC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1944
p.R56C	DO48174	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1944
p.R56H	TCGA-IB-7651	PAAD	TCGA	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1944
p.R56H	DO46657	PAAD	ICGC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1944
p.R56H	SIDM00217	Colorectal Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1944
p.R56H	ACH-000999	Colon/Colorectal Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1944
p.R56H	SNU-1040	large intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1944
p.L19F	DO219064	BLCA	ICGC	SESGIVPDF	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1111
p.L4P	DO219918	DLBC	ICGC	SESGIVPDF	DEG_COP1_1	3:11	Mutation altering degron motif	0.7582
p.Y3F	DO233887	GACA	ICGC	SESGIVPDF	DEG_COP1_1	3:11	Mutation altering degron motif	0.8639
p.M8I	DO229035	LICA	ICGC	SESGIVPDF	DEG_COP1_1	3:11	Mutation altering degron motif	0.7618
p.E2G	DO50906	LICA	ICGC	SESGIVPDF	DEG_COP1_1	3:11	Mutation substituting flanking lysine	0.4167
p.Y7C	DO23525	LIRI	ICGC	SESGIVPDF	DEG_COP1_1	3:11	Mutation altering degron motif	0.7087
p.E15K	DO222595	MELA	ICGC	SESGIVPDF	DEG_COP1_1	3:11	Mutation rewiring degron network	0.2222
p.R60C	DO35442	PACA	ICGC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.0833
p.H40L	DO46925	RECA	ICGC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1389
p.S5L	DO47911	STAD	ICGC	SESGIVPDF	DEG_COP1_1	3:11	Mutation altering degron motif	0.7667
p.F16L	DO41644	UCEC	ICGC	SESGIVPDF	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1944
p.V6F	SIDM00845	Burkitt's Lymphoma	GDSC	SESGIVPDF	DEG_COP1_1	3:11	Mutation altering degron motif	0.7068
p.I48L	SIDM00845	Burkitt's Lymphoma	GDSC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.6063
p.I48L	SIDM01519	Head and Neck Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.6063
p.I48L	ACH-000786	Lymphoma	CCLE	PISSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.6063
p.I48L	ACH-000992	Head and Neck Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.6063
p.S52T	SIDM00845	Burkitt's Lymphoma	GDSC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.3056
p.S52T	SIDM01519	Head and Neck Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.3056
p.S52T	ACH-000786	Lymphoma	CCLE	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.3056
p.S52T	ACH-000992	Head and Neck Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.3056
p.S52T	Daudi	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.3056
p.Y18C	SIDM00585	Hepatocellular Carcinoma	GDSC	SESGIVPDF	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.Y18C	HuH-7	liver	COSMIC	SESGIVPDF	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.A43T	ACH-002101	Lung Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.2222
p.A43T	EMC-BAC-1	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.2222
p.A55V	22RV1	prostate	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation blocking phosphorylation signal	0.6667
p.A42T	EMC-BAC-1	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1944
p.E17K	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	SESGIVPDF	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1667
p.P39A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1111
p.P39A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1111
p.R55H	SNU-1040	large intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation blocking phosphorylation signal	0.6667
p.R40H	SNU-1040	large intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1389
p.R4H	SNU-1040	large intestine	COSMIC	SESGIVPDF	DEG_COP1_1	3:11	Mutation altering degron motif	0.8244
p.R57H	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1667
p.S51T	Daudi	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation altering degron motif	0.7116
p.T58M	PF-382	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.1389
p.A14T	HCC2998	large intestine	COSMIC	SESGIVPDF	DEG_COP1_1	3:11	Mutation rewiring degron network	0.25
p.R21H	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	SESGIVPDF	DEG_COP1_1	3:11	Mutation rewiring degron network	0.0556
p.E43D	SNU-81	large intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	47:51	Mutation rewiring degron network	0.2222

Kaplan plot for MITF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MITF

UniProt ID: O75030

Entrez ID: 4286

Protein name: Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MITF in