DegronMD

Uniprot ID: O75030

Source protein: Microphthalmia-associated transcription factor

Source gene: MITF

Class: DEG_COP1_1

Location: 3:11

E3 ligase: COP1

DEGRON score: 0.9237

ASA_SCORE: 63.7778

COIL: 0.7522

CONS_SCORE: 0.7094

DSS_SCORE: 0.7366

HELIX: 0.055

FCONS_SCORE: 1.0076

RIG_SCORE: 0.6934

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H18R	TCGA-EO-A22R	UCEC	TCGA	SESGIVPDF	DEG_COP1_1	0.1389
p.H18R	DO42713	UCEC	ICGC	SESGIVPDF	DEG_COP1_1	0.1389
p.L19F	DO219064	BLCA	ICGC	SESGIVPDF	DEG_COP1_1	0.1111
p.L4P	DO219918	DLBC	ICGC	SESGIVPDF	DEG_COP1_1	0.7582
p.Y3F	DO233887	GACA	ICGC	SESGIVPDF	DEG_COP1_1	0.8639
p.M8I	DO229035	LICA	ICGC	SESGIVPDF	DEG_COP1_1	0.7618
p.E2G	DO50906	LICA	ICGC	SESGIVPDF	DEG_COP1_1	0.4167
p.Y7C	DO23525	LIRI	ICGC	SESGIVPDF	DEG_COP1_1	0.7087
p.E15K	DO222595	MELA	ICGC	SESGIVPDF	DEG_COP1_1	0.2222
p.S5L	DO47911	STAD	ICGC	SESGIVPDF	DEG_COP1_1	0.7667
p.F16L	DO41644	UCEC	ICGC	SESGIVPDF	DEG_COP1_1	0.1944
p.V6F	SIDM00845	Burkitt's Lymphoma	GDSC	SESGIVPDF	DEG_COP1_1	0.7068
p.Y18C	SIDM00585	Hepatocellular Carcinoma	GDSC	SESGIVPDF	DEG_COP1_1	0.1389
p.Y18C	HuH-7	liver	COSMIC	SESGIVPDF	DEG_COP1_1	0.1389
p.E17K	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	SESGIVPDF	DEG_COP1_1	0.1667
p.R4H	SNU-1040	large_intestine	COSMIC	SESGIVPDF	DEG_COP1_1	0.8244
p.A14T	HCC2998	large_intestine	COSMIC	SESGIVPDF	DEG_COP1_1	0.25
p.R21H	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	SESGIVPDF	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75030	Microphthalmia-associated transcription factor	DEG_COP1_1	3:11	SESGIVPDF	COP1	0.9237	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons