DegronMD

Uniprot ID: O75030

Source protein: Microphthalmia-associated transcription factor

Source gene: MITF

Class: DEG_SPOP_SBC_1

Location: 47:51

E3 ligase: SPOP

DEGRON score: 0.9949

ASA_SCORE: 75.9

COIL: 0.894

CONS_SCORE: 0.7246

DSS_SCORE: 0.6992

HELIX: 0.0638

FCONS_SCORE: 0.9918

RIG_SCORE: 0.5571

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S51F	TCGA-AC-A23H	BRCA	TCGA	PISSS	DEG_SPOP_SBC_1	0.9093
p.S51F	DO2401	BRCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.9093
p.R60H	TCGA-AX-A1CE	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	0.0833
p.R60H	DO42280	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	0.0833
p.S49R	TCGA-BR-6452	STAD	TCGA	PISSS	DEG_SPOP_SBC_1	0.8538
p.S49R	DO38404	STAD	ICGC	PISSS	DEG_SPOP_SBC_1	0.8538
p.A38T	TCGA-CM-6172	COAD	TCGA	PISSS	DEG_SPOP_SBC_1	0.0833
p.A38T	DO8376	COAD	ICGC	PISSS	DEG_SPOP_SBC_1	0.0833
p.M53L	TCGA-DI-A1BU	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	0.2778
p.M53L	DO42023	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	0.2778
p.R56C	TCGA-EY-A549	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	0.1944
p.R56C	DO230335	COCA	ICGC	PISSS	DEG_SPOP_SBC_1	0.1944
p.R56C	DO48174	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	0.1944
p.R56H	TCGA-IB-7651	PAAD	TCGA	PISSS	DEG_SPOP_SBC_1	0.1944
p.R56H	DO46657	PAAD	ICGC	PISSS	DEG_SPOP_SBC_1	0.1944
p.R56H	SIDM00217	Colorectal Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.1944
p.R56H	ACH-000999	Colon/Colorectal Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	0.1944
p.R56H	SNU-1040	large_intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1944
p.R60C	DO35442	PACA	ICGC	PISSS	DEG_SPOP_SBC_1	0.0833
p.H40L	DO46925	RECA	ICGC	PISSS	DEG_SPOP_SBC_1	0.1389
p.I48L	SIDM00845	Burkitt's Lymphoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.6063
p.I48L	SIDM01519	Head and Neck Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.6063
p.I48L	ACH-000786	Lymphoma	CCLE	PISSS	DEG_SPOP_SBC_1	0.6063
p.I48L	ACH-000992	Head and Neck Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	0.6063
p.S52T	SIDM00845	Burkitt's Lymphoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.3056
p.S52T	SIDM01519	Head and Neck Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	0.3056
p.S52T	ACH-000786	Lymphoma	CCLE	PISSS	DEG_SPOP_SBC_1	0.3056
p.S52T	ACH-000992	Head and Neck Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	0.3056
p.S52T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	0.3056
p.A43T	ACH-002101	Lung Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	0.2222
p.A43T	EMC-BAC-1	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	0.2222
p.A55V	22RV1	prostate	COSMIC	PISSS	DEG_SPOP_SBC_1	0.6667
p.A42T	EMC-BAC-1	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1944
p.P39A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1111
p.P39A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1111
p.R55H	SNU-1040	large_intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	0.6667
p.R40H	SNU-1040	large_intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1389
p.R57H	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1667
p.S51T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	0.7116
p.T58M	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	0.1389
p.E43D	SNU-81	large_intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15444	C-C motif chemokine 25	DEG_SPOP_SBC_1	132:136	PISSS	SPOP	0.8813	More...
O75030	Microphthalmia-associated transcription factor	DEG_SPOP_SBC_1	47:51	PISSS	SPOP	0.9949	More...
O94864	STAGA complex 65 subunit gamma	DEG_SPOP_SBC_1	11:15	PISSS	SPOP	0.9981	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	314:318	PISSS	SPOP	0.9982	More...
P26367	Paired box protein Pax-6	DEG_SPOP_SBC_1	286:290	PISSS	SPOP	0.8502	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	586:590	PISSS	SPOP	0.963	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	931:935	PISSS	SPOP	0.9118	More...
Q8IZH2	5'-3' exoribonuclease 1	DEG_SPOP_SBC_1	1684:1688	PISSS	SPOP	0.9961	More...
Q8N983	39S ribosomal protein L43, mitochondrial	DEG_SPOP_SBC_1	184:188	PISSS	SPOP	0.8798	More...
Q92908	Transcription factor GATA-6	DEG_SPOP_SBC_1	38:42	PISSS	SPOP	0.7589	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	532:536	PISSS	SPOP	0.9978	More...
Q7M4L6	SH2 domain-containing adapter protein F	DEG_SPOP_SBC_1	62:66	PISSS	SPOP	0.9333	More...
A6NIR3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5	DEG_SPOP_SBC_1	354:358	PISSS	SPOP	0.9883	More...
Q5VTM2	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9	DEG_SPOP_SBC_1	399:403	PISSS	SPOP	0.9606	More...
Q5VUJ5	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9817	More...
Q5VW22	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6	DEG_SPOP_SBC_1	331:335	PISSS	SPOP	0.9118	More...
Q8TF27	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11	DEG_SPOP_SBC_1	193:197	PISSS	SPOP	0.9254	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1507:1511	PISSS	SPOP	0.9387	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISSS

Degron related mutations and impact score

Drug responses associated with MITF mutations

All proteins holding degron of PISSS