DegronMD - Q8IZH2(XRN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1323T	TCGA-10-0931	OV	TCGA	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation rewiring degron network	0.1944
p.A1323T	DO28631	OV	ICGC	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation rewiring degron network	0.1944
p.L1322V	TCGA-19-5956	GBM	TCGA	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation rewiring degron network	0.1667
p.L1322V	DO13863	GBM	ICGC	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation rewiring degron network	0.1667
p.I1327V	TCGA-5M-AAT6	COAD	TCGA	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation rewiring degron network	0.3056
p.I1327V	DO223703	COAD	ICGC	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation rewiring degron network	0.3056
p.H1338Y	TCGA-A5-A0G2	UCEC	TCGA	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation rewiring degron network	0.1667
p.H1338Y	DO41235	UCEC	ICGC	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation rewiring degron network	0.1667
p.D129E	TCGA-AA-A010	COAD	TCGA	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.2222
p.A141T	TCGA-B5-A3FA	UCEC	TCGA	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.25
p.A141T	DO52402	UCEC	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.25
p.R1690K	TCGA-FD-A62O	BLCA	TCGA	PISSS	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.2778
p.R1690K	DO44069	BLCA	ICGC	PISSS	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.2778
p.C132Y	TCGA-J9-A8CN	PRAD	TCGA	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.3056
p.C132Y	DO219269	PRAD	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.3056
p.E145K	DO217844	BRCA	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.1389
p.D147Y	DO3110	BRCA	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.0833
p.D147Y	DO50420	PRAD	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.0833
p.P135Q	DO228948	LICA	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation altering degron motif	0.7035
p.A141D	DO229018	LICA	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.25
p.P124H	DO229022	LICA	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.0833
p.L130I	DO229032	LICA	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.25
p.H1679Q	DO229045	LICA	ICGC	PISSS	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.1944
p.L1695M	DO229008	LICA	ICGC	PISSS	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.1389
p.G136E	DO50970	LICA	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation altering degron motif	0.6087
p.N1698S	DO50906	LICA	ICGC	PISSS	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.0556
p.I1677V	DO45127	LIRI	ICGC	PISSS	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.1389
p.R138W	DO220911	MELA	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation altering degron motif	0.8634
p.D135Y	DO229232	THCA	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation altering degron motif	0.7325
p.R125Q	DO40884	UCEC	ICGC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.1111
p.E1330A	SIDM01198	Burkitt's Lymphoma	GDSC	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation altering degron motif	0.7701
p.E1330A	SIDM00180	Kidney Carcinoma	GDSC	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation altering degron motif	0.7701
p.E1330A	SIDM01645	Non-Cancerous	GDSC	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation altering degron motif	0.7701
p.K148T	SIDM01237	Hepatocellular Carcinoma	GDSC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation substituting flanking lysine	0.1667
p.K148T	ACH-001021	Liver Cancer	CCLE	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation substituting flanking lysine	0.1667
p.K148T	C3A	liver	COSMIC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation substituting flanking lysine	0.1667
p.D129Y	SIDM00681	Colorectal Carcinoma	GDSC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.2222
p.D129Y	ACH-000252	Colon/Colorectal Cancer	CCLE	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.2222
p.D129Y	LS-1034	large intestine	COSMIC	ITPGTE	DEG_SCF_FBW7_2	133:138	Mutation rewiring degron network	0.2222
p.V1333A	SIDM01045	Endometrial Carcinoma	GDSC	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation rewiring degron network	0.3056
p.V1333A	ACH-000978	Endometrial/Uterine Cancer	CCLE	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation rewiring degron network	0.3056
p.V1333A	EN	endometrium	COSMIC	SKENE	DEG_APCC_KENBOX_2	1328:1332	Mutation rewiring degron network	0.3056

Kaplan plot for XRN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XRN1

UniProt ID: Q8IZH2

Entrez ID: 54464

Protein name: 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XRN1 in