DegronMD

Uniprot ID: Q8IZH2

Source protein: 5'-3' exoribonuclease 1

Source gene: XRN1

Class: DEG_APCC_KENBOX_2

Location: 1328:1332

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9861

ASA_SCORE: 112.34

COIL: 0.7964

CONS_SCORE: 0.2639

DSS_SCORE: 0.6179

HELIX: 0.1966

FCONS_SCORE: 1.0657

RIG_SCORE: 0.6333

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1323T	TCGA-10-0931	OV	TCGA	SKENE	DEG_APCC_KENBOX_2	0.1944
p.A1323T	DO28631	OV	ICGC	SKENE	DEG_APCC_KENBOX_2	0.1944
p.L1322V	TCGA-19-5956	GBM	TCGA	SKENE	DEG_APCC_KENBOX_2	0.1667
p.L1322V	DO13863	GBM	ICGC	SKENE	DEG_APCC_KENBOX_2	0.1667
p.I1327V	TCGA-5M-AAT6	COAD	TCGA	SKENE	DEG_APCC_KENBOX_2	0.3056
p.I1327V	DO223703	COAD	ICGC	SKENE	DEG_APCC_KENBOX_2	0.3056
p.H1338Y	TCGA-A5-A0G2	UCEC	TCGA	SKENE	DEG_APCC_KENBOX_2	0.1667
p.H1338Y	DO41235	UCEC	ICGC	SKENE	DEG_APCC_KENBOX_2	0.1667
p.E1330A	SIDM01198	Burkitt's Lymphoma	GDSC	SKENE	DEG_APCC_KENBOX_2	0.7701
p.E1330A	SIDM00180	Kidney Carcinoma	GDSC	SKENE	DEG_APCC_KENBOX_2	0.7701
p.E1330A	SIDM01645	Non-Cancerous	GDSC	SKENE	DEG_APCC_KENBOX_2	0.7701
p.V1333A	SIDM01045	Endometrial Carcinoma	GDSC	SKENE	DEG_APCC_KENBOX_2	0.3056
p.V1333A	ACH-000978	Endometrial/Uterine Cancer	CCLE	SKENE	DEG_APCC_KENBOX_2	0.3056
p.V1333A	EN	endometrium	COSMIC	SKENE	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZH2	5'-3' exoribonuclease 1	DEG_APCC_KENBOX_2	1328:1332	SKENE	APC,CDC20,FZR1	0.9861	More...
Q9Y6X8	Zinc fingers and homeoboxes protein 2	DEG_APCC_KENBOX_2	55:59	SKENE	APC,CDC20,FZR1	0.7935	More...
Q6P6B1	Glutamate-rich protein 5	DEG_APCC_KENBOX_2	222:226	SKENE	APC,CDC20,FZR1	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons