DegronMD

Uniprot ID: Q9Y6X8

Source protein: Zinc fingers and homeoboxes protein 2

Source gene: ZHX2

Class: DEG_APCC_KENBOX_2

Location: 55:59

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7935

ASA_SCORE: 114.18

COIL: 0.7388

CONS_SCORE: 0.2189

DSS_SCORE: 0.4952

HELIX: 0.2386

FCONS_SCORE: 0.8631

RIG_SCORE: 0.7169

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M66I	TCGA-66-2771	LUSC	TCGA	SKENE	DEG_APCC_KENBOX_2	0.1389
p.M66I	DO26870	LUSC	ICGC	SKENE	DEG_APCC_KENBOX_2	0.1389
p.S54C	TCGA-A8-A092	BRCA	TCGA	SKENE	DEG_APCC_KENBOX_2	0.3056
p.S54C	TCGA-AC-A23H	BRCA	TCGA	SKENE	DEG_APCC_KENBOX_2	0.3056
p.S54C	DO2401	BRCA	ICGC	SKENE	DEG_APCC_KENBOX_2	0.3056
p.S54C	DO4796	BRCA	ICGC	SKENE	DEG_APCC_KENBOX_2	0.3056
p.S54C	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	SKENE	DEG_APCC_KENBOX_2	0.3056
p.S54C	ACH-002215	Lymphoma	CCLE	SKENE	DEG_APCC_KENBOX_2	0.3056
p.S54C	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	SKENE	DEG_APCC_KENBOX_2	0.3056
p.E50K	TCGA-AC-A23H	BRCA	TCGA	SKENE	DEG_APCC_KENBOX_2	0.1944
p.E50K	DO2401	BRCA	ICGC	SKENE	DEG_APCC_KENBOX_2	0.1944
p.L51F	TCGA-AP-A1DK	UCEC	TCGA	SKENE	DEG_APCC_KENBOX_2	0.2222
p.L51F	DO42033	UCEC	ICGC	SKENE	DEG_APCC_KENBOX_2	0.2222
p.S65F	TCGA-BS-A0UV	UCEC	TCGA	SKENE	DEG_APCC_KENBOX_2	0.1667
p.S65F	DO42793	UCEC	ICGC	SKENE	DEG_APCC_KENBOX_2	0.1667
p.E68K	TCGA-EE-A3JI	SKCM	TCGA	SKENE	DEG_APCC_KENBOX_2	0.0833
p.E68K	DO47268	SKCM	ICGC	SKENE	DEG_APCC_KENBOX_2	0.0833
p.E59K	TCGA-L5-A8NM	ESCA	TCGA	SKENE	DEG_APCC_KENBOX_2	0.591
p.E62Q	TCGA-TN-A7HL	HNSC	TCGA	SKENE	DEG_APCC_KENBOX_2	0.25
p.E62Q	DO219080	HNSC	ICGC	SKENE	DEG_APCC_KENBOX_2	0.25
p.S54F	DO1076	BRCA	ICGC	SKENE	DEG_APCC_KENBOX_2	0.3056
p.E59G	DO45299	LIRI	ICGC	SKENE	DEG_APCC_KENBOX_2	0.6087
p.V63L	SIDM00516	Melanoma	GDSC	SKENE	DEG_APCC_KENBOX_2	0.2222
p.V63L	SIDM01879	Non-Cancerous	GDSC	SKENE	DEG_APCC_KENBOX_2	0.2222
p.V63L	ACH-002361	Non-Cancerous	CCLE	SKENE	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZH2	5'-3' exoribonuclease 1	DEG_APCC_KENBOX_2	1328:1332	SKENE	APC,CDC20,FZR1	0.9861	More...
Q9Y6X8	Zinc fingers and homeoboxes protein 2	DEG_APCC_KENBOX_2	55:59	SKENE	APC,CDC20,FZR1	0.7935	More...
Q6P6B1	Glutamate-rich protein 5	DEG_APCC_KENBOX_2	222:226	SKENE	APC,CDC20,FZR1	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons