DegronMD

Uniprot ID: Q6P6B1

Source protein: Glutamate-rich protein 5

Source gene: ERICH5

Class: DEG_APCC_KENBOX_2

Location: 222:226

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.993

ASA_SCORE: 112

COIL: 0.9166

CONS_SCORE: 0.8025

DSS_SCORE: 0.6358

HELIX: 0.0516

FCONS_SCORE: 1.0791

RIG_SCORE: 0.6889

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A215T	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	SKENE	DEG_APCC_KENBOX_2	0.1389
p.A215T	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	SKENE	DEG_APCC_KENBOX_2	0.1389
p.E226D	SIDM00143	Small Cell Lung Carcinoma	GDSC	SKENE	DEG_APCC_KENBOX_2	0.5647
p.A215D	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	SKENE	DEG_APCC_KENBOX_2	0.1389
p.A215D	HCC-15	lung	COSMIC	SKENE	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZH2	5'-3' exoribonuclease 1	DEG_APCC_KENBOX_2	1328:1332	SKENE	APC,CDC20,FZR1	0.9861	More...
Q9Y6X8	Zinc fingers and homeoboxes protein 2	DEG_APCC_KENBOX_2	55:59	SKENE	APC,CDC20,FZR1	0.7935	More...
Q6P6B1	Glutamate-rich protein 5	DEG_APCC_KENBOX_2	222:226	SKENE	APC,CDC20,FZR1	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons