DegronMD - Q9Y6X8(ZHX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M66I	TCGA-66-2771	LUSC	TCGA	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.1389
p.M66I	DO26870	LUSC	ICGC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.1389
p.S54C	TCGA-A8-A092	BRCA	TCGA	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.S54C	TCGA-AC-A23H	BRCA	TCGA	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.S54C	DO2401	BRCA	ICGC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.S54C	DO4796	BRCA	ICGC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.S54C	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.S54C	ACH-002215	Lymphoma	CCLE	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.S54C	BC-3	haematopoietic and lymphoid tissue	COSMIC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.E50K	TCGA-AC-A23H	BRCA	TCGA	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.1944
p.E50K	DO2401	BRCA	ICGC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.1944
p.L51F	TCGA-AP-A1DK	UCEC	TCGA	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2222
p.L51F	DO42033	UCEC	ICGC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2222
p.S65F	TCGA-BS-A0UV	UCEC	TCGA	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.1667
p.S65F	DO42793	UCEC	ICGC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.1667
p.P185L	TCGA-EE-A20C	SKCM	TCGA	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.25
p.P185L	DO222775	MELA	ICGC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.25
p.P185L	DO47665	SKCM	ICGC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.25
p.E68K	TCGA-EE-A3JI	SKCM	TCGA	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.0833
p.E68K	DO47268	SKCM	ICGC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.0833
p.T184I	TCGA-EO-A3B0	UCEC	TCGA	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.2778
p.T184I	DO219773	UCEC	ICGC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.2778
p.P189S	TCGA-FU-A3HZ	CESC	TCGA	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.1389
p.P189S	DO6308	CESC	ICGC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.1389
p.E59K	TCGA-L5-A8NM	ESCA	TCGA	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation altering degron motif	0.591
p.E62Q	TCGA-TN-A7HL	HNSC	TCGA	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.25
p.E62Q	DO219080	HNSC	ICGC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.25
p.S54F	DO1076	BRCA	ICGC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.3056
p.S180L	DO8264	COAD	ICGC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation altering degron motif	0.6556
p.G173R	DO48270	ESCA	ICGC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.25
p.I186N	DO228155	LIAD	ICGC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.2222
p.M187I	DO231937	LICA	ICGC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.1944
p.E59G	DO45299	LIRI	ICGC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation altering degron motif	0.6087
p.T167A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.0833
p.T167A	SIDM00683	Prostate Carcinoma	GDSC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.0833
p.T167A	ACH-000914	Lymphoma	CCLE	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.0833
p.T167A	ACH-000977	lymph node	CCLE	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.0833
p.T167A	LNCaP-Clone-FGC	prostate	COSMIC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.0833
p.T167A	HT	haematopoietic and lymphoid tissue	COSMIC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.0833
p.G169S	SIDM00128	Head and Neck Carcinoma	GDSC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.1389
p.G169S	ACH-002249	Head and Neck Cancer	CCLE	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.1389
p.G169S	JHU-011	upper aerodigestive tract	COSMIC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.1389
p.T172A	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.2222
p.T172A	NCI-H1299	lung	COSMIC	DSGISVS	DEG_SCF_TRCP1_1	176:182	Mutation rewiring degron network	0.2222
p.V63L	SIDM00516	Melanoma	GDSC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2222
p.V63L	SIDM01879	Non-Cancerous	GDSC	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2222
p.V63L	ACH-002361	Non-Cancerous	CCLE	SKENE	DEG_APCC_KENBOX_2	55:59	Mutation rewiring degron network	0.2222

Kaplan plot for ZHX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZHX2

UniProt ID: Q9Y6X8

Entrez ID: 22882

Protein name: Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZHX2 in