DegronMD

Uniprot ID: Q9Y6X8

Source protein: Zinc fingers and homeoboxes protein 2

Source gene: ZHX2

Class: DEG_SCF_TRCP1_1

Location: 176:182

E3 ligase: BTRC

DEGRON score: 0.9749

ASA_SCORE: 78.1143

COIL: 0.9149

CONS_SCORE: 0.5089

DSS_SCORE: 0.6571

HELIX: 0.028

FCONS_SCORE: 0.9761

RIG_SCORE: 0.6414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P185L	TCGA-EE-A20C	SKCM	TCGA	DSGISVS	DEG_SCF_TRCP1_1	0.25
p.P185L	DO222775	MELA	ICGC	DSGISVS	DEG_SCF_TRCP1_1	0.25
p.P185L	DO47665	SKCM	ICGC	DSGISVS	DEG_SCF_TRCP1_1	0.25
p.T184I	TCGA-EO-A3B0	UCEC	TCGA	DSGISVS	DEG_SCF_TRCP1_1	0.2778
p.T184I	DO219773	UCEC	ICGC	DSGISVS	DEG_SCF_TRCP1_1	0.2778
p.P189S	TCGA-FU-A3HZ	CESC	TCGA	DSGISVS	DEG_SCF_TRCP1_1	0.1389
p.P189S	DO6308	CESC	ICGC	DSGISVS	DEG_SCF_TRCP1_1	0.1389
p.S180L	DO8264	COAD	ICGC	DSGISVS	DEG_SCF_TRCP1_1	0.6556
p.G173R	DO48270	ESCA	ICGC	DSGISVS	DEG_SCF_TRCP1_1	0.25
p.I186N	DO228155	LIAD	ICGC	DSGISVS	DEG_SCF_TRCP1_1	0.2222
p.M187I	DO231937	LICA	ICGC	DSGISVS	DEG_SCF_TRCP1_1	0.1944
p.T167A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGISVS	DEG_SCF_TRCP1_1	0.0833
p.T167A	SIDM00683	Prostate Carcinoma	GDSC	DSGISVS	DEG_SCF_TRCP1_1	0.0833
p.T167A	ACH-000914	Lymphoma	CCLE	DSGISVS	DEG_SCF_TRCP1_1	0.0833
p.T167A	ACH-000977	lymph_node	CCLE	DSGISVS	DEG_SCF_TRCP1_1	0.0833
p.T167A	LNCaP-Clone-FGC	prostate	COSMIC	DSGISVS	DEG_SCF_TRCP1_1	0.0833
p.T167A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	DSGISVS	DEG_SCF_TRCP1_1	0.0833
p.G169S	SIDM00128	Head and Neck Carcinoma	GDSC	DSGISVS	DEG_SCF_TRCP1_1	0.1389
p.G169S	ACH-002249	Head and Neck Cancer	CCLE	DSGISVS	DEG_SCF_TRCP1_1	0.1389
p.G169S	JHU-011	upper_aerodigestive_tract	COSMIC	DSGISVS	DEG_SCF_TRCP1_1	0.1389
p.T172A	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	DSGISVS	DEG_SCF_TRCP1_1	0.2222
p.T172A	NCI-H1299	lung	COSMIC	DSGISVS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6X8	Zinc fingers and homeoboxes protein 2	DEG_SCF_TRCP1_1	176:182	DSGISVS	BTRC	0.9749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons